Objective The development of methods to isolate and generate human stem cells along with technology to selectively differentiate them into specific cell and tissue types has excited many with the promise of the ability to study human cell function and utilise them for regeneration in disease and trauma. However, to date, attempts to develop regenerative brain and central nervous system therapies have been disappointing, with the introduced stem cell derived neurons not integrating nor signalling physiologically with endogenous cells. A major confounding issue has been that derived neurons are grown in two dimensions, which does not mimic the in vivo three dimensional interactions nor the myriad developmental cues they would receive in vivo. We will develop functional three dimensional human stem cell derived neural networks of defined and reproducible architecture, based on that of a brain cortical module that will display in vivo connectivity and activity. The networks will be seeded on nano-scale designed femtosecond laser printed scaffolds using novel polymerisation methods that will allow electrical stimulation, simultaneous recording and light sheet imaging during development and at maturation to interrogate network function. Cells will be seeded at and will develop at specific, defined points on the network scaffold, enabling the growth of realistic and reproducible functional neuronal networks. The proposal seeks to provide fabricated reproducible scaffolds that can be produced on a large scale. These concepts are far outside what is currently pursued in the field. The development of such a technological platform will be foundational for a new era of biological and medical research based on human neural networks. Cellular neuroscience research and pharmaceutical drug discovery will be transformed and we envisage that within 15 years iPSC derived networks from individual patients will be re-implanted to treat conditions such as Parkinson’s disease, dementia and trauma Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Call for proposal H2020-FETOPEN-2014-2015 See other projects for this call Sub call H2020-FETOPEN-2014-2015-RIA Funding Scheme RIA - Research and Innovation action Coordinator ASTON UNIVERSITY Net EU contribution € 839 016,01 Address ASTON TRIANGLE B4 7ET Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 839 016,25 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LZH LASERZENTRUM HANNOVER EV Germany Net EU contribution € 520 625,00 Address HOLLERITHALLEE 8 30419 Hannover See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Niedersachsen Hannover Region Hannover Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 520 625,00 FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Spain Net EU contribution € 558 125,00 Address AVINGUDA CARL FRIEDRICH GAUSS 3 08860 Castelldefels See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 558 125,00 UNIVERSITAT DE BARCELONA Spain Net EU contribution € 484 986,25 Address GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 484 986,76 AXOL BIOSCIENCE LTD United Kingdom Net EU contribution € 711 480,74 Address SUITE 3 THE SCIENCE VILLAGE CHESTERFORD RESEARCH P CB10 1XL Cambridge See on map Region East of England Essex West Essex Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 711 480,74 KITE INNOVATION (EUROPE) LIMITED Participation ended United Kingdom Net EU contribution € 23 605,49 Address 3M BUCKLEY INNOVATION CENTRE HD1 3BD Huddersfield See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Yorkshire and the Humber West Yorkshire Calderdale and Kirklees Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 23 605,49 DLM CONSULTANCY SERVICES LTD United Kingdom Net EU contribution € 88 052,01 Address 3M BUCKLEY INNOVATION CENTRE HD1 3BD Huddersfield See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Yorkshire and the Humber West Yorkshire Calderdale and Kirklees Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 88 052,01
