Obiettivo Resolution of acute inflammation, involving limiting further leukocyte recruitment, apoptosis and clearanceof inflammatory cells via macrophages as well as egress of the inflammatory cells, is operative in acuteinflammation but dysfunctional in chronic inflammatory disease. In the latter scenario, the retention andactivation of leukocytes in the inflamed tissue linked with failure to resolve inflammation contributes toperpetuation of organ damage and loss of homeostasis. Interestingly, persistent inflammation in insulintargetorgans, such as the adipose tissue and the liver in the context of obesity significantly contributes todevelopment of insulin resistance (IR), diabetes and non-alcoholic fatty liver disease (NAFLD). So far,investigations have mainly addressed obesity-related inflammatory mechanisms in the AT and rather less inother metabolic organs, e.g. the liver. Therefore, the aims of this proposal are: (i) To characterize in thecontext of obesity-related metabolic disease novel processes mediating inflammatory cell retention,especially in the liver. In this context, we will also address the novel hypothesis that adhesive interactions ofinflammatory cells (with e.g. parenchymal cells) in the metabolically challenged environment of obeseorgans may activate them via alterations in their cellular metabolism, thereby contributing to perpetuation ofinflammation. (ii) To understand resolution of inflammation including inflammatory cell egress frommetabolic organs, especially from the liver in metabolic-inflammatory disease. To this end, we will alsoutilize models of acute inflammation, which is capable to resolve, in order to understand resolution principlesand apply them to non-resolving metabolic-inflammatory disease. In this regard, we will also assess thetherapeutic potential of novel inflammation-modulating factors identified by our lab. Campo scientifico medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinehepatologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Parole chiave Inflammation Leukocyte adhesion obesity Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-CoG-2015 - ERC Consolidator Grant Invito a presentare proposte ERC-2015-CoG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-COG - Consolidator Grant Istituzione ospitante TECHNISCHE UNIVERSITAET DRESDEN Contribution nette de l'UE € 1 953 250,00 Indirizzo HELMHOLTZSTRASSE 10 01069 Dresden Germania Mostra sulla mappa Regione Sachsen Dresden Dresden, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 953 250,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto TECHNISCHE UNIVERSITAET DRESDEN Germania Contribution nette de l'UE € 1 953 250,00 Indirizzo HELMHOLTZSTRASSE 10 01069 Dresden Mostra sulla mappa Regione Sachsen Dresden Dresden, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 953 250,00