Cel Resolution of acute inflammation, involving limiting further leukocyte recruitment, apoptosis and clearanceof inflammatory cells via macrophages as well as egress of the inflammatory cells, is operative in acuteinflammation but dysfunctional in chronic inflammatory disease. In the latter scenario, the retention andactivation of leukocytes in the inflamed tissue linked with failure to resolve inflammation contributes toperpetuation of organ damage and loss of homeostasis. Interestingly, persistent inflammation in insulintargetorgans, such as the adipose tissue and the liver in the context of obesity significantly contributes todevelopment of insulin resistance (IR), diabetes and non-alcoholic fatty liver disease (NAFLD). So far,investigations have mainly addressed obesity-related inflammatory mechanisms in the AT and rather less inother metabolic organs, e.g. the liver. Therefore, the aims of this proposal are: (i) To characterize in thecontext of obesity-related metabolic disease novel processes mediating inflammatory cell retention,especially in the liver. In this context, we will also address the novel hypothesis that adhesive interactions ofinflammatory cells (with e.g. parenchymal cells) in the metabolically challenged environment of obeseorgans may activate them via alterations in their cellular metabolism, thereby contributing to perpetuation ofinflammation. (ii) To understand resolution of inflammation including inflammatory cell egress frommetabolic organs, especially from the liver in metabolic-inflammatory disease. To this end, we will alsoutilize models of acute inflammation, which is capable to resolve, in order to understand resolution principlesand apply them to non-resolving metabolic-inflammatory disease. In this regard, we will also assess thetherapeutic potential of novel inflammation-modulating factors identified by our lab. Dziedzina nauki medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinehepatologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Słowa kluczowe Inflammation Leukocyte adhesion obesity Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-CoG-2015 - ERC Consolidator Grant Zaproszenie do składania wniosków ERC-2015-CoG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-COG - Consolidator Grant Instytucja przyjmująca TECHNISCHE UNIVERSITAET DRESDEN Wkład UE netto € 1 953 250,00 Adres HELMHOLTZSTRASSE 10 01069 Dresden Niemcy Zobacz na mapie Region Sachsen Dresden Dresden, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 953 250,00 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko TECHNISCHE UNIVERSITAET DRESDEN Niemcy Wkład UE netto € 1 953 250,00 Adres HELMHOLTZSTRASSE 10 01069 Dresden Zobacz na mapie Region Sachsen Dresden Dresden, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 953 250,00
