COmplete Nucleic acid ANalysis at genome scale using ultra high throughput sequencing

Projektinformationen

CONAN

ID Finanzhilfevereinbarung: 729198

DOI 10.3030/729198

Projekt abgeschlossen

EK-Unterschriftsdatum 21 Juni 2016

Startdatum 1 Juli 2016

Enddatum 31 Dezember 2016

Finanziert unter

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Gesamtkosten € 71 429,00

EU-Beitrag € 50 000,00

Koordiniert durch

DEPIXUS
France

Ziel

The human genome project has not fully delivered the benefits promised in terms of cost and utility. Complete genome sequencing still costs greater than 1,000€ and offers most people limited value (for example in terms of immediate health benefits). New levels of genetic complexity have been uncovered with the discovery of different types of molecular switches that control the activity of the genes coded by the DNA. It is clear now that full genome analysis requires not just the raw DNA sequence, but a complete reading of the many DNA modifications now known to exist in vivo (for example, 5-mC) and a comprehensive analysis of the dynamic population of RNA within the cell. Complete genome analysis therefore requires the DNA sequence as well as epigenetic and transcriptomic information. Current NGS systems can only indirectly obtain a partial picture of these important aspects of the genome after performing costly sample processing. Based on the pioneering biophysics work of the LPS and carried forward by PicoSeq with the support of several large research grants, we are developing a disruptive technology capable of directly sequencing DNA and RNA, and detecting a wide range of base modifications on responsible for epigenetic changes. This new platform called SIMDEQ (SIngle Molecule Magnetic Detection and Quantification). Our current prototype system is capable of complete nucleic acid analysis, but is limited in its throughput, and is thus limited in its commercial applications. The problem of the limited range of data produced by current NGS technologies will be solved in this program by combining our unique SIMDEQ approach with the advanced manufacturing technologies common in the micro-electronics industry. The core of this project is the development of the CONAN chip, which brings together microwell structures, microscale magnets integrated onto the chip around each well and a digital readout of the relevant signal from each DNA or RNA molecule under examination

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acids
• natural sciences › biological sciences › genetics › DNA
• natural sciences › physical sciences › electromagnetism and electronics › microelectronics
• natural sciences › biological sciences › genetics › RNA
• natural sciences › biological sciences › genetics › genomes

Programm/Programme

• H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Main Programme
• H2020-EU.2.1.5. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced manufacturing and processing
• H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials
• H2020-EU.2.3.1. - Mainstreaming SME support, especially through a dedicated instrument

Thema/Themen

• SMEInst-02-2016-2017 - Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs

Aufforderung zur Vorschlagseinreichung

H2020-SMEInst-2016-2017

Andere Projekte für diesen Aufruf anzeigen

Unterauftrag

H2020-SMEINST-1-2016-2017

Finanzierungsplan

SME-1 - SME instrument phase 1

Koordinator

DEPIXUS

• Netto-EU-Beitrag: € 50 000,00
• Adresse: 3-5 IMPASSE REILLE ; 75014 Paris ; Frankreich
• KMU Die Organisation definierte sich zum Zeitpunkt der Unterzeichnung der Finanzhilfevereinbarung selbst als KMU (Kleine und mittlere Unternehmen). Ja:
  Region
  Ile-de-France › Ile-de-France › Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Gesamtkosten: € 71 429,00