Objective
Major Depression (MD) is often chronic and characterized by frequent recurrences of symptoms and burden. The need to better understand how and when relevant transitions in symptoms occur is urgent. A seemingly unsolvable scientific problem is the enormous etiological complexity of mental disorders such as MD, involving continuously ongoing gene-environment interactions that act in highly person-specific ways. This hampers accurate assessment of personalized risk.
I will use an out-of-the-box and interdisciplinary approach to tackle this problem. MD is not the only phenomenon that is influenced by many factors, is unpredictable and makes sudden transitions. This is also the case for other so-called complex dynamical systems such as climate or water quality of lakes. For the latter systems generic early warning signals (EWS) have been found that indicate the approach of a transition. I hypothesize that transitions in mood can be anticipated using the same generic EWS as reported for other complex dynamical systems.
Finding direct evidence for this hypothesis requires a completely novel approach in the field of psychiatry, which would involve (i) a design that captures data of the complete dynamic process within a single individual in order to detect the timing of EWS and sudden transitions in symptoms, prospectively and intra-individually, and (ii) frequent replications of these individual experiments. With help of recent technology and my acquired expertise I will use precisely this novel approach to search for personalized EWS that anticipate critical transitions in depression. This is the aim of my project.
Evidence that transitions in mood behave according to principles of complex dynamical systems would change the field majorly. First, it would lead to a new understanding of mental disorders and the way we study them. Second, it would yield a sophisticated novel way of obtaining personalized and clinically relevant information on risk for transitions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencescomputer and information sciencessoftware
- medical and health sciencesclinical medicinepsychiatry
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesearth and related environmental scienceshydrology
- natural sciencesmathematicsapplied mathematicsdynamical systems
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Programme(s)
Funding Scheme
ERC-COG - Consolidator GrantHost institution
9713 GZ Groningen
Netherlands