Obiettivo The progress in liquid chromatography (LC), basically following Moore’s law over the last decade, will soon come to a halt. LC is the current state-of-the-art chemical separation method to measure the composition of complex mixtures. Driven by the ever growing complexity of the samples in e.g. environmental and biomedical research, LC is constantly pushed to higher efficiencies. Using highly optimized and monodisperse spherical particles, randomly packed in high pressure columns, the progress in LC has up till now been realized by reducing the particle size and concomitantly increasing the pressure. With pressure already up at 1500 bar, groundbreaking progress is still badly needed, e.g. to fully unravel the complex reaction networks in human cells.For this purpose, it is proposed to leave the randomly packed bed paradigm and move to structures wherein the 1 to 5 micrometer particles currently used in LC are arranged in perfectly ordered and open-structured geometries. This is now possible, as the latest advances in nano-manufacturing and positioning allow proposing and developing an inventive high-throughput particle assembly and deposition strategy. The PI's ability to develop new parts of chromatography will be used to rationally optimize the many possible geometries accessible through this disruptive new technology, and identify those structures coping best with any remaining degree of disorder. Using the PI's experimental know-how on microfluidic chromatography systems, these structures will be used to pursue the disruptive gain margin (order of factor 100 in separation speed) that is expected based on general chromatography theory. Testing this groundbreaking new generation of LC columns together with world-leading bio-analytical scientists will illustrate their potential in making new discoveries in biology and life sciences. The new nano-assembly strategies might also be pushed to other applications, such as photonic crystals. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid dynamicscomputational fluid dynamicsnatural sciencesmathematicspure mathematicsgeometrysocial scienceslaw Parole chiave Separation science Liquid chromatography Microfluidics Lab-on-a-chip Ordered hierarchical materials Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-ADG-2015 - ERC Advanced Grant Invito a presentare proposte ERC-2015-AdG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-ADG - Advanced Grant Istituzione ospitante VRIJE UNIVERSITEIT BRUSSEL Contribution nette de l'UE € 2 488 812,50 Indirizzo PLEINLAAN 2 1050 Bruxelles / Brussel Belgio Mostra sulla mappa Regione Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 488 812,50 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto VRIJE UNIVERSITEIT BRUSSEL Belgio Contribution nette de l'UE € 2 488 812,50 Indirizzo PLEINLAAN 2 1050 Bruxelles / Brussel Mostra sulla mappa Regione Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 488 812,50