Cel I propose an integrated programme of molecular genetic studies to fill fundamental gaps in our knowledge of sex chromosome evolution. Specifically, I will use a fish, the guppy (Poecilia reticulata), to test the sexual antagonism (SA) hypothesis of sex chromosome evolution, which is plausible, but lacks direct evidence. SA mutations (that benefit one sex but lower fitness of the other) are proposed to arise in a partially sex-linked (pseudo-autosomal region, or PAR) gene, and establish polymorphisms. To reduce the conflict between the sexes, suppressed recombination between X and Y chromosomes then evolves (unless sex-specific expression evolves first). The guppy is ideal for studying this hypothesis because SA polymorphisms are well documented: male coloration phenotypes make males attractive to females, but also make them conspicuous to predators (while females gain no compensating benefit). Moreover, guppies have a recombination-suppressed sex-linked region that carries multiple coloration genes, yet is thought to have evolved recently. However, no non-Y-linked coloration factor has yet been mapped, and the genetics is complicated by modifers making some XX individuals male, and by male-specific expression of some phenotypes. I will map coloration genes and identify PAR genes using DNA-based markers to take account of these problems. I will test for the predicted lower coloration allele frequencies in natural populations with high versus low predation rates, and do population genetic analyses to test for closer linkage under high predation. I will also use X-Y sequence divergence to estimate the age of the guppy sex chromosome. The project tests predictions that emerge from well-documented differing selection regimes in natural guppy populations. I have therefore assembled a team of collaborators experienced with guppies who can provide behavioural and ecological genetic expertise to complement the strength of my own group in molecular evolutionary genetics. Dziedzina nauki natural sciencesbiological sciencesbiological behavioural sciencesethologybiological interactionsnatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticshereditynatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesgeneticsgenomes Słowa kluczowe Sex chromosomes recombination suppression Sexual antagonism Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-ADG-2015 - ERC Advanced Grant Zaproszenie do składania wniosków ERC-2015-AdG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-ADG - Advanced Grant Instytucja przyjmująca THE UNIVERSITY OF EDINBURGH Wkład UE netto € 930 607,50 Adres OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Zjednoczone Królestwo Zobacz na mapie Region Scotland Eastern Scotland Edinburgh Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 930 607,50 Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko THE UNIVERSITY OF EDINBURGH Zjednoczone Królestwo Wkład UE netto € 930 607,50 Adres OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Zobacz na mapie Region Scotland Eastern Scotland Edinburgh Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 930 607,50 THE UNIVERSITY OF EXETER Zjednoczone Królestwo Wkład UE netto € 619 627,50 Adres THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter Zobacz na mapie Region South West (England) Devon Devon CC Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 619 627,50