Objective
Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g. cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing. Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative DNA damage and repair have not emerged. Here, we will study mechanisms of nucleotide metabolism and oxidative DNA damage and repair, and generate tools and make use of ‘omics’ approaches to explore the function of the Nudix and glycosylases family enzymes in relation to oxidative metabolism. Furthermore, we will progress and understand the basic mechanisms how oxidative DNA lesions are processed and kill cells. Importantly, we will develop small molecule inhibitors targeting Nudix and glycosylases, e.g. MTH1, NUDT15 and OGG1, and use our newly developed inhibitors to increase our knowledge of these enzymes in oxidative metabolism and disease. We will further optimize these inhibitors into drugs and explore therapeutic approaches in cancer and inflammation as well as in exploratory studies in a variety of diseases involving oxidative stress. Altogether, in this programme we contribute to deepen our knowledge into the fundamental biology of oxidative stress and its links with disease, and providing the scientific community with an innovative repertoire of selective inhibitors for numerous enzymes involved in repair of oxidative lesions. This will enable exploratory basic science discoveries as well as potential novel therapeutic interventions ‘outside the box’. The programme will also generate high value to the industrial competitiveness of Europe in form of novel inhibitors for treatment of diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-AdG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.