Objective
The global burden of cancer, calculated as the cost of years lost from ill-health, disability or early death, currently outweighs all other health concerns including cardiovascular diseases . Among all cancers, metastatic melanoma (MM) represents one of the major health problems. Unlike other solid tumors, which mainly affect older adults, MM is notorious for affecting young and middle-aged people, results in 66000 related deaths yearly worldwide (World Health Organization) and therefore has a large impact on years of healthy life lost.
Recently, promising results of autologous cell therapy (ACT) with tumour infiltrating lymphocytes (TILs) have shown that up to 20% of patients can be cured with one single course of this immunotherapy . This treatment has been conducted at a handful of institutions with over 1.000 patients treated worldwide. The resulting survival rates of patients treated confirm this approach as being among the most efficient therapies available. Importantly, this novel treatment has the potential to be expanded to the treatment of other cancer types.
However, there is a need for dedicated bioreactors for the expansion of TILs for the individual patients. Bioreactors that can provide high cell densities and high absolute cell numbers. Further, TIL production for ACT is labour intensive and must be performed in a sterile cleanroom. This limits the use of this new and efficient cancer treatment to a few highly specialised hospitals. The aim of this application is to develop a dedicated bioreactor that will enable the treatment to be used on an extended number of hospitals. The commercial potential for ACT is estimated to be more than 4 Billion $ per year. .
This project is therefore seen as relevant for the topic: Supporting innovative SMEs in the healthcare biotechnology sector - SMEInst-05-2016-2017 Publication date: 14 October 2015.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being
MAIN PROGRAMME
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H2020-EU.3.1.3. - Treating and managing disease
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-1 - SME instrument phase 1
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-SMEInst-2016-2017
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3460 Birkerod
Denmark
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.