Objective
Finding simple solutions to complex problems has been a challenge for humankind for decades. VERDI aims at designing a multifunctional nanosystem to heal complex bone diseases. This is an engineering challenge that will be tackled through the use of building blocks designed on the basis of cutting-edge technology. These building blocks will be assembled into a versatile multifunctional nanosystem that can be adapted through slight variations for the treatment of three diseases of clinical relevance: bone infection, bone cancer and osteoporosis. The novelty of this proposal is the design of a nanosystem that may address several diseases using a unique, versatile and scalable strategy. Mesoporous silica nanoparticles are selected as the main component of the nanoplatform because of their biocompatibility, robustness, loading capacity and versatile surface modification. The nanosystem will be modified by rational selection of building blocks, with targeting and/or therapeutic abilities, to tackle either one or a combination of pathologies. These features will enable us to deliver a library of nanomedicines using a toolbox of building blocks, customizing a specific nanosystem depending on the disease to be treated. The risks associated to VERDI are numerous, such as the great complexity of producing completely asymmetrical nanoparticles (NPs), the risk that modifying a drug or therapeutic peptide will affect its therapeutic efficacy, and the difficulty of achieving effective in vivo bone targeted NPs. A contingency plan for each risk has been elaborated. The expertise and capacities of my research group guarantees successful results, which we expect to lead to a revolution in the therapy of bone cancer, bone infection and osteoporosis. Additionally, the application of a single technology for the treatment of three different but frequently associated diseases will favour industrial scale-up process, thereby promoting the transition of nanomedicine from bench to bedside.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine immunology
- medical and health sciences medical biotechnology nanomedicine
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-AdG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28040 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.