Sieving neuronal network communication

Projektinformationen

MESOTAS-SIEVE

ID Finanzhilfevereinbarung: 713732

DOI 10.3030/713732

Abgeschlossenes Projekt

EK-Unterschriftsdatum 12 September 2016

Startdatum 1 Oktober 2016

Enddatum 31 März 2018

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 150 000,00

EU-Beitrag € 150 000,00

Koordiniert durch

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Ziel

This project will demonstrate the technical and commercial viability of the MESOTAS-SIEVE bioreactor, a novel 3D brain-on-chip microculture system. This allows the culturing and in vitro functional analysis of neuronal networks that mimic the human brain in a physiologically much more relevant way than conventional cell culture systems or animal models. Therefore, the MESOTAS-SIEVE system has great potential towards the realisation of tissue models of the brain for drug efficacy and toxicity assays.
This project is based on exciting discoveries done in the ERC Starting Grant project MESOTAS (2011-2016). In MESOTAS, a bioreactor on a microelectrode array (MEA) has been developed to study the ‘natural’ behaviour of 3D neuronal networks. For this bioreactor, a neuronal cell line has been identified that uniquely survives >30 days and forms neuronal networks. To further improve function and network formation capacity, this project will integrate a micro-sieve at the bottom of the MESOTAS bioreactor to improve cell shape, function and optimal connection to the MEA electrodes for single-cell readout of activity. PoC of this MESOTAS-SIEVE bioreactor provides the basis for further development towards a commercial brain-on-a-chip platform.
The first steps towards commercialization of MESOTAS-SIEVE will be performed as part of this project and initial industry contact are already in place. During the project we will establish a solid business model, including intellectual property (IP) protection, a market/competitor analysis, and an exploitation plan. Towards the end of this project the “data package” will be used to attract further financing towards commercialization.

Wissenschaftliches Gebiet

• engineering and technology › environmental biotechnology › bioremediation › bioreactors
• social sciences › economics and business › business and management › business models
• natural sciences › mathematics › pure mathematics › mathematical analysis › functional analysis

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-PoC-2015 - ERC Proof of Concept Grant

Aufforderung zur Vorschlagseinreichung

ERC-2015-PoC

Finanzierungsplan

ERC-POC - Proof of Concept Grant

Gastgebende Einrichtung

TECHNISCHE UNIVERSITEIT EINDHOVEN

• Netto-EU-Beitrag: € 150 000,00
• Adresse: GROENE LOPER 3 ; 5612 AE Eindhoven ; Niederlande
• Region: Zuid-Nederland › Noord-Brabant › Zuidoost-Noord-Brabant
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 150 000,00

Begünstigte (1)

TECHNISCHE UNIVERSITEIT EINDHOVEN

Niederlande

• Netto-EU-Beitrag: € 150 000,00
• Adresse: GROENE LOPER 3 ; 5612 AE Eindhoven
• Region: Zuid-Nederland › Noord-Brabant › Zuidoost-Noord-Brabant
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 150 000,00