Objectif Innovative problem solving is critical for all spheres of organised endeavour, including science and industry, and thus forms the cornerstone of a successful society. Such creative thinking often requires suppression of preconceptions and restructuring of existing knowledge. Pioneering work has shown that sleep facilitates problem solving, but exactly how, and which sleep characteristics are important, remain to be determined. We know that recent experiences are replayed in sleep, and that in Slow Wave Sleep (SWS) this replay integrates new knowledge with old. The role of such replay in Rapid Eye Movement (REM) sleep, a stage which is strongly linked to creativity, is unknown. Here, I propose a model which combines physiology, behavioural studies, and computational modelling to make testable predictions about the complimentary contributions of memory replay in REM and SWS to problem solving. I will test this model through explicit manipulation of memory replay in sleep. I will use a very recently developed technique to explicitly trigger memory replay, a pioneering method for quantifying this replay, and cutting-edge approaches for manipulation of neural oscillations during sleep. I expect two key results: first, I will uncover the principles of how memory replay in REM and SWS combines with specific neural oscillations to promote both long-term memory and creative problem solving. This will involve development of a computational model which will enable optimised experimental design, paving the way for efficient future investigation of how to enhance innovation through manipulation of sleep. Second, I will develop methods for boosting key sleep processes in a selective, targeted manner. Immediate consequences will include a translational project to facilitate everyday problem solving. My findings will revolutionist the understanding of sleep and how it impacts upon some of our most important cognitive abilities—memory and problem solving. Champ scientifique social sciencespsychologybehavioural psychologymedical and health sciencesbasic medicinephysiology Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-CoG-2015 - ERC Consolidator Grant Appel à propositions ERC-2015-CoG Voir d’autres projets de cet appel Régime de financement ERC-COG - Consolidator Grant Institution d’accueil CARDIFF UNIVERSITY Contribution nette de l'UE € 1 999 195,00 Adresse NEWPORT ROAD 30 36 CF24 0DE Cardiff Royaume-Uni Voir sur la carte Région Wales East Wales Cardiff and Vale of Glamorgan Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 999 195,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire CARDIFF UNIVERSITY Royaume-Uni Contribution nette de l'UE € 1 999 195,00 Adresse NEWPORT ROAD 30 36 CF24 0DE Cardiff Voir sur la carte Région Wales East Wales Cardiff and Vale of Glamorgan Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 999 195,00
