Design of double network polycarbonate-based hydrogels by simultaneous reactions: scaffolds for load-bearing soft tissue regeneration

Projektinformationen

DN-CARTILOGEL

ID Finanzhilfevereinbarung: 703415

DOI 10.3030/703415

Projekt abgeschlossen

EK-Unterschriftsdatum 4 März 2016

Startdatum 12 September 2016

Enddatum 11 September 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 183 454,81

EU-Beitrag € 183 454,80

Koordiniert durch

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

Ziel

Polymer materials have outstanding properties with which to be applied for a wide range of applications. In particular, hydrogel materials are widely studied for applications in tissue engineering on account of their high water contents. Despite the advances in these materials, some biomedical targets remain challenging. Articular cartilage (AC) is the white flexible load-bearing soft tissue able to withstand the highest loads in physically demanding areas of the body. Once it is damaged, its poor ability for self-repair may induce a progressive loss of function that, ultimately, results in a severe musculoskeletal degenerative condition. While most commonly used hydrogel fabrication techniques still have practical limitations or do not lead to materials that are sufficiently strong for AC regeneration, the DN-Cartilogel project proposes the preparation of innovative tough, double network hydrogel materials that are based on advanced hydrophilic poly(carbonate)s. The tailored design of polymers with specific side-chain and end group functionalities will lead to hydrogel materials with improved mechanical strength, toughness and high water content. To this end, the project will apply the one-step synthetic methodology based on orthogonal click chemistry that was reported recently by the host group to generate novel and highly tunable materials. The ultimate goal is to develop a straightforward path to design robust DN hydrogels able to induce the differentiation of mesenchymal stem cells into specialized cartilage-producing cells, which directly addresses priorities established by the H2020 Work Programme.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › inorganic chemistry › inorganic compounds
• medical and health sciences › medical biotechnology › tissue engineering
• natural sciences › chemical sciences › polymer sciences
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• engineering and technology › industrial biotechnology › biomaterials

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2015

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

THE UNIVERSITY OF BIRMINGHAM

• Netto-EU-Beitrag: € 41 022,78
• Adresse: Edgbaston ; B15 2TT Birmingham ; Vereinigtes Königreich
• Region: West Midlands (England) › West Midlands › Birmingham
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 41 022,79

Beteiligte (1)

UNIVERSITY OF WARWICK

Beteiligung beendet

Vereinigtes Königreich

• Netto-EU-Beitrag: € 142 432,02
• Adresse: KIRBY CORNER ROAD UNIVERSITY HOUSE ; CV4 8UW COVENTRY
• Region: West Midlands (England) › West Midlands › Coventry
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 142 432,02