CombiCatProject ID: 702385
Combined Catalysis: Enhancing Asymmetric Synthesis
Total cost:EUR 183 454,80
EU contribution:EUR 183 454,80
Coordinated in:United Kingdom
Call for proposal:H2020-MSCA-IF-2015See other projects for this call
The stereoselective synthesis of small organic molecules depends on robust catalytic methods. Despite many advances in enantioselective synthesis, an unsolved challenge in catalysis is the translation of enantioselective catalytic reactions to diastereoselective reactions – where a chiral catalyst controls the outcome of reaction of a chiral substrate.
In this proposal, we seek to investigate this 'double stereodifferentiation' in various organocatalytic reactions, and in transition metal-catalyzed cycloisomerization, two fields which take advantage of the expertise of the host group and the experienced researcher. We further aim to explore the union of these two fields using 'Combined catalysis' – specifically, in dual catalytic processes through which we seek to improve stereoselective syntheses of small organic molecules attractive to the pharmaceutical industry. The culmination of the project will be cascade dual catalytic processes, where the organocatalyst serves to activate the substrate towards metal-catalyzed cycloisomerization, and also to mediate a further asymmetric synthetic transformation.
The successful completion of these goals will require the combined expertise of the two project partners: in metal catalysis (the host group) and organocatalysis (the ER), with the proposal being based on preliminary results in both areas.
EU contribution: EUR 183 454,80
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