Objective This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life. Fields of science medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiamedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesmedical biotechnologyimplantsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Keywords Central Pattern Generator Large scale nonlinear optimization Cardio-respiratory disease Adaptive electronics Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.2. - FET Proactive Topic(s) FETPROACT-01-2016 - FET Proactive: emerging themes and communities Call for proposal H2020-FETPROACT-2016-2017 See other projects for this call Sub call FETPROACT-2016 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITY OF BATH Net EU contribution € 1 548 936,25 Address Claverton down BA2 7AY Bath United Kingdom See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 548 936,25 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY OF BRISTOL Participation ended United Kingdom Net EU contribution € 431 668,75 Address Beacon house queens road BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 431 668,75 UNIVERSITAT ZURICH Switzerland Net EU contribution € 833 367,50 Address Ramistrasse 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 833 367,50 MICROCHIP TECHNOLOGY CALDICOT LIMITED United Kingdom Net EU contribution € 403 125,00 Address Phase 2 castlegate business park NP26 5YW Gwent See on map Region Wales East Wales Monmouthshire and Newport Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 403 125,00 MEDTRONIC BAKKEN RESEARCH CENTER B.V. Netherlands Net EU contribution € 550 000,00 Address Endepolsdomein 5 6229GW Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 550 000,00 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 584 375,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 584 375,00 UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands Net EU contribution € 490 625,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 490 625,00 FAKULTNI NEMOCNICE U SV ANNY V BRNE Czechia Net EU contribution € 102 250,00 Address Pekarska 53 602 00 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 102 250,00