Objective
In biochemical systems, combinations of specialized molecular entities are precisely arranged to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates in enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Control mechanisms based on the cooperative binding of signal substances regulate the enzyme’s action, and complicated feedback loops may apply.
Since the advent of supramolecular chemistry, scientists construct artificial systems with ever increasing complexity and functionality that promise to serve as the basis for future developments in bottom-up nanotechnology with applications in medicine (drug delivery), diagnostics, catalysis, material science and molecular photonics/electronics.
Self-assembly of functional entities with pre-programmed connectivities has produced an impressive line-up of nanoscopic architectures such as coordination cages that recognize and transform molecular substrates. Most of these systems are based on one sort of ligand, joined by one kind of metal ion. My group has reported a number of cages, each equipped with a unique, single function such as chirality, redox-activity, light-switching, allosteric regulation or endohedral binding sites.
While all these mono-functionalized cages contribute to the progress of supramolecular architecture, nature demonstrates that the key to the most sophisticated systems lies in multi-functionalized structures.
As breakthrough strategies for achieving this level of complexity with artificial systems we propose:
1) Heteroleptic coordination of ligands by a [Pd2Ligand4]-platform-specific way of steric fine-tuning
2) Biopolymer-inspired folding of a modular chain of covalently joined building blocks
Combined with our recent achievements in host-guest switching, we aim at adjustable receptors, controllable molecular reaction chambers and multifunctional photo/redox systems
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences polymer sciences
- natural sciences chemical sciences organic chemistry heterocyclic compounds
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-CoG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
44227 Dortmund
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.