Multicellular regulation of insulin secretion from pancreatic islets

Projektinformationen

OptoBETA

ID Finanzhilfevereinbarung: 715884

DOI 10.3030/715884

Abgeschlossenes Projekt

EK-Unterschriftsdatum 25 November 2016

Startdatum 1 Juni 2017

Enddatum 30 November 2022

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 681 468,00

EU-Beitrag € 1 681 468,00

Koordiniert durch

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

Ziel

Type 2 diabetes mellitus, one of the major healthcare challenges of our time, is characterized by failure of beta cells to functionally adapt to increased peripheral insulin resistance. The resulting chronic elevations in blood glucose concentration are associated with heart, kidney, liver, nerve and retinal disease, as well as cancer. Here, by combining novel optogenetic, photopharmacological and innovative imaging approaches, we aim to unravel the complexity underlying the multicellular regulation of insulin secretion from islets of Langerhans during health and disease. In particular, we will examine a role for privileged pacemakers/hubs in orchestrating population responses to stimuli, identify what makes these specialized cells unique at the RNA/protein level, and understand how they contribute to islet development and failure. Furthermore, we will address whether the intraislet regulation of insulin secretion operates in vivo to determine glucose homeostasis, focusing on the neural-endocrine interface. Lastly, the mechanisms underlying islet cross-talk will be investigated directly in situ within the pancreas of living mice, paying close attention to the roles of the vasculature and secreted factors. As such, these studies should unveil a new route for restoration of insulin secretion in man, as well as provide the foundation for the de novo construction of islets for transplantation.

Wissenschaftliches Gebiet

• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases
• medical and health sciences › clinical medicine › transplantation
• medical and health sciences › health sciences › nutrition › obesity

Schlüsselbegriffe

• type 2 diabetes
• beta cell
• islet

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2016-STG - ERC Starting Grant

Aufforderung zur Vorschlagseinreichung

ERC-2016-STG

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

THE UNIVERSITY OF BIRMINGHAM

• Netto-EU-Beitrag: € 1 681 468,00
• Adresse: Edgbaston ; B15 2TT Birmingham ; Vereinigtes Königreich
• Region: West Midlands (England) › West Midlands › Birmingham
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 681 468,00

Begünstigte (1)

THE UNIVERSITY OF BIRMINGHAM

Vereinigtes Königreich

• Netto-EU-Beitrag: € 1 681 468,00
• Adresse: Edgbaston ; B15 2TT Birmingham
• Region: West Midlands (England) › West Midlands › Birmingham
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 681 468,00