Objectif We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolicstudy of tissues at the system level.Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease. Champ scientifique natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopymedical and health sciencesclinical medicinehepatologynatural sciencesmathematicspure mathematicsgeometrynatural scienceschemical sciencesphysical chemistry Mots‑clés Nuclear Magnetic Resonance Tissue Slice Culture Liver Pathology Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Appel à propositions H2020-FETOPEN-2016-2017 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-1-2016-2017 Régime de financement RIA - Research and Innovation action Coordinateur UNIVERSITY OF SOUTHAMPTON Contribution nette de l'UE € 1 256 126,25 Adresse Highfield SO17 1BJ Southampton Royaume-Uni Voir sur la carte Région South East (England) Hampshire and Isle of Wight Southampton Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 256 126,25 Participants (2) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire RIJKSUNIVERSITEIT GRONINGEN Pays-Bas Contribution nette de l'UE € 935 121,25 Adresse Broerstraat 5 9712CP Groningen Voir sur la carte Région Noord-Nederland Groningen Overig Groningen Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 935 121,25 KARLSRUHER INSTITUT FUER TECHNOLOGIE Allemagne Contribution nette de l'UE € 947 185,00 Adresse KAISERSTRASSE 12 76131 Karlsruhe Voir sur la carte Région Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 947 185,00