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Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic Understanding of Liver Function And Disease

Cel

We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic
study of tissues at the system level.

Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level.
The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.

It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.

TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease.

Zaproszenie do składania wniosków

H2020-FETOPEN-2016-2017

Zobacz inne projekty w ramach tego zaproszenia

Szczegółowe działanie

H2020-FETOPEN-1-2016-2017

Koordynator

UNIVERSITY OF SOUTHAMPTON
Wkład UE netto
€ 1 256 126,25
Adres
Highfield
SO17 1BJ Southampton
Zjednoczone Królestwo

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Region
South East (England) Hampshire and Isle of Wight Southampton
Rodzaj działalności
Higher or Secondary Education Establishments
Linki
Koszt całkowity
€ 1 256 126,25

Uczestnicy (2)