Cel We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolicstudy of tissues at the system level.Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease. Dziedzina nauki natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopymedical and health sciencesclinical medicinehepatologynatural sciencesmathematicspure mathematicsgeometrynatural scienceschemical sciencesphysical chemistry Słowa kluczowe Nuclear Magnetic Resonance Tissue Slice Culture Liver Pathology Program(-y) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Temat(-y) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Zaproszenie do składania wniosków H2020-FETOPEN-2016-2017 Zobacz inne projekty w ramach tego zaproszenia Szczegółowe działanie H2020-FETOPEN-1-2016-2017 System finansowania RIA - Research and Innovation action Koordynator UNIVERSITY OF SOUTHAMPTON Wkład UE netto € 1 256 126,25 Adres Highfield SO17 1BJ Southampton Zjednoczone Królestwo Zobacz na mapie Region South East (England) Hampshire and Isle of Wight Southampton Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 256 126,25 Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko RIJKSUNIVERSITEIT GRONINGEN Niderlandy Wkład UE netto € 935 121,25 Adres Broerstraat 5 9712CP Groningen Zobacz na mapie Region Noord-Nederland Groningen Overig Groningen Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 935 121,25 KARLSRUHER INSTITUT FUER TECHNOLOGIE Niemcy Wkład UE netto € 947 185,00 Adres KAISERSTRASSE 12 76131 Karlsruhe Zobacz na mapie Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 947 185,00