Objective
Transposable elements (TEs) account for more than two thirds of the human genome. They can inactivate
genes, provide novel coding functions, sprinkle chromosomes with recombination-prone repetitive
sequences, and modulate cellular gene expression through a wide variety of transcriptional and
posttranscriptional influences. As a consequence, TEs are considered as essential motors of evolution yet
they are occasionally associated with disease, causing about one hundred Mendelian disorders and possibly
contributing to several human cancers. As expected for such genomic threats, TEs are subjected to tight
epigenetic control imposed from the very first days of embryogenesis, in part owing to their recognition by
sequence-specific RNA- and protein-based repressors. It is generally considered that the evolutionary
selection of these TE controllers reflects a simple host-pathogen arms race, and that their action results in the
early and permanent silencing of their targets. We have recently uncovered new evolutionary evidence and
obtained genomic and functional data that invalidate this dual assumption, and suggest instead that
transposable elements and their epigenetic controllers establish species-specific transcriptional networks that
play critical roles in human development and physiology. The general objective of the present proposal is to
explore the breadth of this phenomenon, to decipher its mechanisms, to unveil its functional implications,
and to probe how this knowledge could be exploited for basic research, biotechnology and clinical medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences other social sciences development studies social developments
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-AdG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.