Objectif Organs-on-chip are expected to play a crucial role in the pharmaceutical industry for drug development and study of organs and diseases. We propose the development of an electrical detector that enables simple, versatile and continuous quality monitoring of these devices and is essential for commercialization. Combined with recent advances in stem cell technology, Organ-on-Chips can be used to do drug screening on an individual level. Therefore it can serve as instrument for personalized medicine, by determining the effectiveness of selected compounds, as well as possible side-effects to determine safe drug doses on a person-specific level. Moreover, Organs-on-Chip will greatly contribute to a further reduction in the need for animal testing. Besides the pharmaceutical industry, Organs-on-Chip hold great promise for the food and cosmetics industry to test the safety of products.Organ-on-Chip systems need continuous monitoring of the quality of the cell barrier to guarantee reliable outcomes of the drug development tests. State-of-the-art methods, such as fluorescence and commercially available Trans-Endothelial Electrical Resistance (TEER) measurement apparatus are discontinuous, inaccurate and/or harmful for the cells and therefore unsuitable for pharmaceutical applications. Our innovation overcomes these disadvantages. It enables continuous quality monitoring of the barrier function of the organ, which is essential for the commercialization of Organs-on-Chip. The BIOS-Lab on Chip group holds an excellent record in high-quality TEER measurements, demonstrating direct current (DC) TEER-measurements in a gut-on-a-chip in a top-15 of most cited research papers in the journal Lab-on-Chip in 2015 and has ample experience in the development of a blood-brain barrier on chip. This proposal is part of the ERC-project Vascular Engineering on-chip using differentiated Stem Cells (VESCEL). Champ scientifique engineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-PoC-2016 - ERC-Proof of Concept-2016 Appel à propositions ERC-2016-PoC Voir d’autres projets de cet appel Régime de financement ERC-POC - Proof of Concept Grant Institution d’accueil UNIVERSITEIT TWENTE Contribution nette de l'UE € 150 000,00 Adresse DRIENERLOLAAN 5 7522 NB Enschede Pays-Bas Voir sur la carte Région Oost-Nederland Overijssel Twente Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 150 000,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSITEIT TWENTE Pays-Bas Contribution nette de l'UE € 150 000,00 Adresse DRIENERLOLAAN 5 7522 NB Enschede Voir sur la carte Région Oost-Nederland Overijssel Twente Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 150 000,00
