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Preclinical validation of a novel immunogenic composition to stimulate innate immunity

Cel

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required.
The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, we
propose pre-clinical development plan in translational mouse models.

Dziedzina nauki

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

ERC-2016-PoC

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System finansowania

ERC-POC - Proof of Concept Grant

Instytucja przyjmująca

INSTITUT CURIE
Wkład UE netto
€ 150 000,00
Adres
RUE D ULM 26
75231 Paris
Francja

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Region
Ile-de-France Ile-de-France Paris
Rodzaj działalności
Research Organisations
Linki
Koszt całkowity
€ 150 000,00

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Ostatnia aktualizacja: 9 Sierpnia 2022

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Permalink: https://cordis.europa.eu/project/id/727408/pl

European Union, 2024