Objetivo Head direction (HD) cells provide directional information during spatial navigation and thus act as aninternal compass. The goal of this study is to understand how the HD circuit creates a lasting neural trace oftransient directional changes. Cells selective for HD have been identified in several brain regions, includingthe retrosplenial cortex (RSC), and display persistent activity in response to transient vestibular turningcues. Although a well-established theoretical framework proposes an elegant circuitry for achieving thisself-sustaining activity, biological evidence for such a circuit is lacking. Studies of HD circuitry have facedsignificant challenges due to the necessity of functional monitoring at large and small scales in vivo, andprecise stimulus control. This study will take advantage of recent advances allowing the targeting of specificcells and their inputs for chronic two-photon imaging in the awake, head-fixed, and passively rotated mouse.Experiments will aim to (1) determine the spatial and temporal organization of HD-tuned responses in RSC,and (2) functionally characterize the presynaptic inputs of HD cells. This information will validate or rejecta prominent theory of neural network organization, and provide unprecedented insight into a poorlyunderstood but critical brain function. Ámbito científico natural sciencesbiological scienceszoologymammalogyprimatologynatural sciencesbiological sciencesneurobiologycognitive neurosciencenatural scienceschemical sciencesinorganic chemistryalkaline earth metalssocial sciencessocial geographytransportnavigation systemsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2016 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2016 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador UNIVERSITETET I OSLO Aportación neta de la UEn € 196 400,40 Dirección PROBLEMVEIEN 5-7 0313 Oslo Noruega Ver en el mapa Región Norge Oslo og Viken Oslo Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 196 400,40