Scaffold hybridization approach targeting PPIs

Projektinformationen

SHAPPI

ID Finanzhilfevereinbarung: 749012

DOI 10.3030/749012

Abgeschlossenes Projekt

EK-Unterschriftsdatum 3 März 2017

Startdatum 1 Mai 2017

Enddatum 30 April 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 183 454,80

EU-Beitrag € 183 454,80

Koordiniert durch

UNIVERSITY OF LEEDS
United Kingdom

Ziel

Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease, hence an outstanding challenge in chemical biology is to develop generic approaches for PPI inhibition. Such inhibitors (or chemical probes) represent unique tools to understand biological processes and starting points for drug discovery, for treatment of multiple illnesses for which effective treatments don’t currently exist e.g. cancer.

SHAPPI will allow Zsofia Hegedus (the fellow) to join the laboratory of Andrew Wilson (host supervisor) at the University of Leeds (Host) and develop research expertise in the area of inhibiting protein-protein interactions. In doing so, she will (a) enhance her prospects to become an independent academic group leader and (b) address the need to train researchers in this key area of chemical biology and (c) develop cutting edge methods that advance peptidomimetic approaches for inhibition of protein-protein interactions. Scaffold hybridization will allow the combination of molecular scaffolds capable of hot spot mimicry with molecules that influence selectivity or potency. In combination with reversible chemistry this will allow generation of dynamic combinatorial libraries of rapid identification of selective and potent inhibitors. The fellowship will explore proteomimetic-peptide conjugates and peptide-small molecule dynamic combinatorial libraries to accelerate development of selective PPI inhibitors using two model interactions; HIF-1α/p300 and BID/BAX, both of which represent important targets for anticancer therapy.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › chemical sciences › organic chemistry › aldehydes
• natural sciences › biological sciences › genetics › RNA
• natural sciences › chemical sciences › organic chemistry › amines
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2016 - Individual Fellowships

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2016

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

UNIVERSITY OF LEEDS

• Netto-EU-Beitrag: € 183 454,80
• Adresse: WOODHOUSE LANE ; LS2 9JT Leeds ; Vereinigtes Königreich
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 183 454,80