Objetivo The central nervous system (CNS) integrates peripheral hormonal signals to regulate glucose homeostasis and feeding behavior. Obesity can cause the development of insulin resistance in the brain and completely disrupt the regulative functions of the CNS. Restoring the brain’s ability to modulate metabolic functions could be very important to prevent the negative outcomes of obesity and diabetes. The Dorsal Vagal Complex (DVC) in the brainstem senses insulin to regulate glucose metabolism and feeding behavior in rodents. Three days of high fat diet feeding (HFD) is sufficient to completely disrupt the insulin response, thus causing an increase in blood glucose levels and overnutrition. I propose to understand the molecular events that trigger the development of insulin resistance in the DVC and understand the neuronal networks involved in the regulation glucose metabolism and feeding behavior in the DVC. I will use a combination of in vitro molecular approaches and in vivo physiological readouts to shed light on the physiological functions of this area of the brain. Identification of novel target molecules that are involved in the development of insulin resistance may also provide the basis for the development of new pharmacological approaches to counteract the development of obesity and diabetes. Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinehepatologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2016 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2016 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-RI - RI – Reintegration panel Coordinador UNIVERSITY OF LEEDS Aportación neta de la UEn € 195 454,80 Dirección WOODHOUSE LANE LS2 9JT Leeds Reino Unido Ver en el mapa Región Yorkshire and the Humber West Yorkshire Leeds Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 195 454,80
