Obiettivo The central nervous system (CNS) integrates peripheral hormonal signals to regulate glucose homeostasis and feeding behavior. Obesity can cause the development of insulin resistance in the brain and completely disrupt the regulative functions of the CNS. Restoring the brain’s ability to modulate metabolic functions could be very important to prevent the negative outcomes of obesity and diabetes. The Dorsal Vagal Complex (DVC) in the brainstem senses insulin to regulate glucose metabolism and feeding behavior in rodents. Three days of high fat diet feeding (HFD) is sufficient to completely disrupt the insulin response, thus causing an increase in blood glucose levels and overnutrition. I propose to understand the molecular events that trigger the development of insulin resistance in the DVC and understand the neuronal networks involved in the regulation glucose metabolism and feeding behavior in the DVC. I will use a combination of in vitro molecular approaches and in vivo physiological readouts to shed light on the physiological functions of this area of the brain. Identification of novel target molecules that are involved in the development of insulin resistance may also provide the basis for the development of new pharmacological approaches to counteract the development of obesity and diabetes. Campo scientifico natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinehepatologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2016 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2016 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-RI - RI – Reintegration panel Coordinatore UNIVERSITY OF LEEDS Contribution nette de l'UE € 195 454,80 Indirizzo WOODHOUSE LANE LS2 9JT Leeds Regno Unito Mostra sulla mappa Regione Yorkshire and the Humber West Yorkshire Leeds Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 195 454,80
