Novel smart glyco-nanomaterials as targeted therapeutics.

Projektinformationen

Glyco-Platforms

ID Finanzhilfevereinbarung: 748103

DOI 10.3030/748103

Abgeschlossenes Projekt

EK-Unterschriftsdatum 16 März 2017

Startdatum 1 Dezember 2017

Enddatum 30 November 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 195 454,80

EU-Beitrag € 195 454,80

Koordiniert durch

UNIVERSITY OF BRISTOL
United Kingdom

Ziel

Cell surface carbohydrates play key roles in cell recognition mechanisms. Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of the cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer. Understanding these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and other cancers to be defined, which will facilitate the development of new effective therapeutics and diagnostic tools for these conditions. The proposal centers on the chemo-enzymatic synthesis of novel multivalent mucin-type O-glycan probes for the screening of O-glycosylation-linked interactions in health and in disease and the development of smart glyco-nanoparticles as drug delivery systems. This is a multidisciplinary project involving synthetic organic and inorganic chemistry and glycobiology.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › clinical medicine › gastroenterology › inflammatory bowel disease
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates
• medical and health sciences › clinical medicine › oncology
• natural sciences › chemical sciences › inorganic chemistry

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2016 - Individual Fellowships

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2016

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

UNIVERSITY OF BRISTOL

• Netto-EU-Beitrag: € 195 454,80
• Adresse: BEACON HOUSE QUEENS ROAD ; BS8 1QU Bristol ; Vereinigtes Königreich
• Region: South West (England) › Gloucestershire, Wiltshire and Bristol/Bath area › Bristol, City of
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 195 454,80