Functions of plasticity in adult-born neurons

Projektinformationen

FUNCOPLAN

ID Finanzhilfevereinbarung: 725729

DOI 10.3030/725729

Abgeschlossenes Projekt

EK-Unterschriftsdatum 20 März 2017

Startdatum 1 Juni 2017

Enddatum 31 Mai 2022

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 2 000 000,00

EU-Beitrag € 2 000 000,00

Koordiniert durch

KING'S COLLEGE LONDON
United Kingdom

Ziel

The major objective of FUNCOPLAN is to examine groundbreaking questions on the functional role of newly-generated neurons in the adult brain. Using a combination of innovative approaches, our aim is to discover how plasticity in adult-born cells shapes information processing in neuronal circuits.

Adult neurogenesis produces new neurons in particular areas of the mammalian brain throughout life. Because they undergo a transient period of heightened plasticity, these freshly-generated cells are believed to bring unique properties to the circuits they join – a continual influx of new, immature cells is believed to provide a level of plasticity not achievable by the mature, resident network alone. But what exactly is the function of the additional plasticity provided by adult-born neurons? How does it influence information processing in neuronal networks?

These questions are vital for our fundamental understanding of how the brain works. We will address them by studying a unique population of cells that is continually generated throughout life: dopaminergic neurons in the olfactory bulb. These cells play a key role in the modulation of early sensory responses and are renowned for their plastic capacity. However, the role of this plasticity in shaping sensory processing remains completely unknown. FUNCOPLAN’s first objectives, therefore, are to discover novel experience-dependent plastic changes in the cellular features and sensory response properties of adult-born neurons. We will then go much further than this, however, by integrating our discoveries with state-of-the-art techniques for precisely manipulating activity in these cells in vivo. This wholly innovative approach will allow us to mimic the effects of plasticity in naïve circuits, or cancel the effects of plasticity in experience-altered networks. In this way, we will break new ground, demonstrating a unique contribution of plasticity in adult-born cells to the fundamental function of neuronal circuitry.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• natural sciences › physical sciences › optics › microscopy
• natural sciences › computer and information sciences › data science › data processing

Schlüsselbegriffe

• FUNCOPLAN

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2016-COG - ERC Consolidator Grant

Aufforderung zur Vorschlagseinreichung

ERC-2016-COG

Finanzierungsplan

ERC-COG - Consolidator Grant

Gastgebende Einrichtung

KING'S COLLEGE LONDON

• Netto-EU-Beitrag: € 2 000 000,00
• Adresse: STRAND ; WC2R 2LS London ; Vereinigtes Königreich
• Region: London › Inner London — West › Westminster
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 000 000,00

Begünstigte (1)

KING'S COLLEGE LONDON

Vereinigtes Königreich

• Netto-EU-Beitrag: € 2 000 000,00
• Adresse: STRAND ; WC2R 2LS London
• Region: London › Inner London — West › Westminster
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 000 000,00