Objectif The gastrointestinal tract is colonized by a community of microbes, the microbiota, which has a significant impact on human health and nutrition. The mucus gel layer structure provides the barrier between the microbiota and the intestine preventing the occurrence of the inflammation process. Indeed, an altered microbiota (towards mucus degrading bacteria) and defects in the mucus structure have been shown to be associated with inflammatory bowel diseases, such as ulcerative colitis.Understanding how members of the microbiota can alter mucin composition, can, potentially, be deployed to ensure that the structure of this ecosystem maximizes human health. This approach, however, is limited by a lack of understanding how mucins are metabolized by the microbiota. Significantly, available genomic/metagenomics sequence data of the microbiota presents an exciting, but so far, unfulfilled, opportunity to make decisive advances in our understanding of mucin degradation by members of this ecosystem. In this project I will seek to combine this genomic information with in vivo studies to understand the mechanisms of mucin utilization by the human microbiota and the impact on UC development. The data from the research programme will underpin the development of future therapeutic strategies to improve human health.The fellow is Portuguese and is now completing her PhD at the Newcastle University, UK. The fellow has experience in enzyme activity screening, enzymatic characterization and structural biology. In this fellowship she will have the opportunity to develop skills in genetic manipulation of anaerobic bacteria, microbiota in vivo (mouse) studies and structural analysis of O-glycans. This fellowship will enable the fellow develop her current skill set to include methodologies and approaches so that the molecular analysis of the target enzymes can be placed within a biological context. Champ scientifique natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesmedical biotechnologygenetic engineeringmedical and health scienceshealth sciencesnutritionnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2016 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2016 Voir d’autres projets de cet appel Régime de financement MSCA-IF-GF - Global Fellowships Coordinateur GOETEBORGS UNIVERSITET Contribution nette de l'UE € 247 059,00 Adresse VASAPARKEN 405 30 Goeteborg Suède Voir sur la carte Région Södra Sverige Västsverige Västra Götalands län Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 247 059,00 Partenaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire Partenaire Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention. UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN États-Unis Contribution nette de l'UE € 0,00 Adresse SOUTH STREET 3003 1068 46109 1274 Ann Arbor Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 160 130,40