Obiettivo The stereocontrolled ring-opening polymerisation (ROP) of chiral cyclic esters for the preparation of biodegradable polymers with precise and finely-tuned properties remains a research challenge. Only Few catalysts/initiators have been reported to produce stereoregular high molecular weight polymers; most of them being highly sensitive and/or toxic organometallic species. Organocatalysed ROP produces polymers that are free of residual metal contaminates but to date, does not allow high productivities with high levels of stereocontrol. In this context, the multi-disciplinary proposal DUAL-PHOSCAT proposes to develop chiral tunable dual phosphorus-based organocatalysts to overcome these challenges. For this, a stepwise-synthesis strategy to tailor the organocatalyst architectures and an inventive combinatorial approach using self-assembled oganocatalysts will be investigated. The stepwise synthesis will bind together using chiral linkers, chiral phosphorus-based molecules and chiral thioureas molecules.The self-assembled dual organocatalysts will be obtained combining chiral amine-thioureas and chiral phosphoric acids. These systems will be investigated for the ROP of rac-lactide and rac-beta-butyrolactone. The proposed catalysts enable great advances in the preparation of isotactic polylactide (PLA) stereocomplex and highly tactic poly-3-hydroxybutyrate (PHB) in terms of catalyst stability, productivity, activity and stereoselectivity, in turn making these catalysts efficient green alternative to sensitive and /or toxic organometallic initiators for the synthesis of metal-free highly stereoregular polyesters under industrially-relevant conditions. The PLA and PHB obtained will find potential applications in packaging and fibers (as green alternative to petroleum-based plastics) or as biomedical devices that is in line with the H2020 programme (e.g. Climate action, environment, resource efficiency and raw materials and Health, Demographic and well-being). Campo scientifico engineering and technologyindustrial biotechnologybiomaterialsbioplasticspolylactic acidnatural scienceschemical sciencespolymer sciencesnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural scienceschemical sciencescatalysisnatural scienceschemical sciencesorganic chemistryamines Parole chiave Ring-opening polymerisation Organocatalysis Biodegradable polymers Asymmetric catalysis self-assembled catalysts Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2016 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2016 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinatore THE UNIVERSITY OF BIRMINGHAM Contribution nette de l'UE € 130 303,20 Indirizzo Edgbaston B15 2TT Birmingham Regno Unito Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 130 303,20 Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto UNIVERSITY OF WARWICK Partecipazione conclusa Regno Unito Contribution nette de l'UE € 65 151,60 Indirizzo KIRBY CORNER ROAD UNIVERSITY HOUSE CV4 8UW COVENTRY Mostra sulla mappa Regione West Midlands (England) West Midlands Coventry Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 65 151,60
