An Integrated Heart Model for the simulation of the cardiac function

Projektinformationen

iHEART

ID Finanzhilfevereinbarung: 740132

DOI 10.3030/740132

Abgeschlossenes Projekt

EK-Unterschriftsdatum 17 Mai 2017

Startdatum 1 Dezember 2017

Enddatum 31 Mai 2023

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 2 351 544,00

EU-Beitrag € 2 351 544,00

Koordiniert durch

POLITECNICO DI MILANO
Italy

Ziel

The goal of this project is to construct, mathematically analyze, numerically approximate, computationally solve, and validate on clinically relevant cases a mathematically-based integrated heart model (IHM) for the human cardiac function. The IHM comprises several core cardiac models – electrophysiology, solid and fluid mechanics, microscopic cellular force generation, and valve dynamics – which are then coupled and finally embedded into the systemic and pulmonary blood circulations. It is a multiscale system of Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs) featuring multiphysics interactions among the core models.

The physical and mathematical properties of each core model and those of the even more complex integrated heart model (IHM) will be analyzed. The numerical approximation of IHM develops along several steps: introduce new high order methods for the core models, carry out their stability and convergence analysis, devise new paradigms for their numerical coupling, and construct optimal, scalable, and adaptive preconditioners for the efficient solution of the resulting large-scale discrete problems. To address data variability in clinically relevant cases, new reduced order models and efficient computational techniques will be developed also for forward and inverse uncertainty quantification problems. Two software libraries, LifeHEART and RedHEART, will be built and made available to the scientific community.

The project is original, very ambitious, mathematically inspired and rigorous, tremendously challenging, and groundbreaking. If successful, it will provide researchers from applied mathematics and life sciences, cardiologists, and cardiac surgeons with a powerful tool for both the qualitative and quantitative study of cardiac function and dysfunction. iHEART has the potential to drive improvements in diagnosis and treatment for cardiovascular pathologies that are responsible for more than 45% of deaths in Europe.

Wissenschaftliches Gebiet

• natural sciences › physical sciences › classical mechanics › fluid mechanics › fluid dynamics
• natural sciences › mathematics › pure mathematics › geometry
• natural sciences › mathematics › pure mathematics › mathematical analysis › differential equations › partial differential equations
• natural sciences › computer and information sciences › artificial intelligence › machine learning
• natural sciences › mathematics › applied mathematics › mathematical model

Schlüsselbegriffe

• Mathematical modeling
• PDEs
• numerical approximation
• stability and convergence analysis
• reduced order models
• uncertainty quantification
• large-scale computing
• application to life science

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2016-ADG - ERC Advanced Grant

Aufforderung zur Vorschlagseinreichung

ERC-2016-ADG

Finanzierungsplan

ERC-ADG - Advanced Grant

Gastgebende Einrichtung

POLITECNICO DI MILANO

• Netto-EU-Beitrag: € 2 351 544,00
• Adresse: PIAZZA LEONARDO DA VINCI 32 ; 20133 Milano ; Italien
• Region: Nord-Ovest › Lombardia › Milano
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 351 544,00

Begünstigte (1)

POLITECNICO DI MILANO

Italien

• Netto-EU-Beitrag: € 2 351 544,00
• Adresse: PIAZZA LEONARDO DA VINCI 32 ; 20133 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 351 544,00