Obiettivo The immune system uses both short- and long-range communication mechanisms to mount the coordinated and sophisticated cellular responses required to control microbial infections or fight tumors. Yet, our understanding of how immunological signals are integrated and propagated by individual cells in complex tissue microenvironments remains largely limited.ENLIGHTEN is a research program dedicated to establish new mechanisms by which the immune system fight tumors or infections, based on the direct manipulation of immunological signals in vivo. In relevant mouse models of human disease, we will combine intravital imaging, fluorescent sensors and optogenetic actuators to control single cell functions in real-time. We wish to understand how T cells sense and interpret cell-contacts in lymphoid organs and in developing tumors at steady state or during immunotherapy. In addition, we aim to establish how cytokine and chemokine gradients form in tissues and are interpreted by immune cells during infection or cancer.By determining the functional contribution of single immune cells in vivo, we aim to identify new paradigms for information transfer in the immune system during cancer or infection and to establish the combination of optogenetics and intravital imaging as a powerful strategy for decoding immune reactions in the context of disease pathogenesis. Campo scientifico natural sciencesphysical sciencesopticsmicroscopyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Parole chiave tumor immunity immunity to infection intravital imaging optogenetics cytokines chemokines Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2016-ADG - ERC Advanced Grant Invito a presentare proposte ERC-2016-ADG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-ADG - Advanced Grant Istituzione ospitante INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Contribution nette de l'UE € 2 499 994,00 Indirizzo RUE DE TOLBIAC 101 75654 Paris Francia Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 499 994,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contribution nette de l'UE € 2 499 994,00 Indirizzo RUE DE TOLBIAC 101 75654 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 499 994,00
