Cel i) Apply quantitative molecular modelling to the design of new and selective reagents for useful synthetic transformations, particularly enantio and diastereo-selective carbon-carbon bond formation. (ii) Develop new approaches to the computational modelling of organic reactions, which have greater accuracy and range of applications relative to existing methods. The ultimate goal in this field is the development of quantitative models for reactions involving all synthetically important elements in the first row of the Periodic Table. (iii) Design and synthesize new and useful organic reagents and molecules, valuable to the chemical industry and in the development of new pharmaceuticals and materials. (iv) Transfer expertise and knowledge within the network in the general areas of stereoselective organic synthesis and molecular modelling. Strengthen the scientific relationships between the participants. (v) Train young scientists within the European Community, particularly at the postdoctoral level, in contemporary organic synthesis and molecular modelling.Quantitative molecular modelling has been applied to the design of new and selective reagents for useful synthetic transformations, particularly enantioselective and diastereoselective carbon carbon bond formation. New approaches to the computational modelling of organic reactions have been developed, which have greater accuracy and range of applications relative to existing methods. Computer assisted design of new chiral boron enolates has been undertaken. A molecular mechanics model of the transition state for the addition of allyl and crotyl boronates to aldehydes has been developed. New enantioselective boron enolates bearing menthone derived chiral ligands have been developed. New stereoselective ketone boron enolates derived from lactate esters have been developed. Enantioselective catalysts for reactions of nitroalkanes have been designed. Synthetic catalysts for amide hydrolysis have been designed. New molecules with interesting conformational properties have been designed. Stereoselective nucleophilic epoxidations of electron poor alkenes have been developed. Approaches to the total synthesis of immunosuppressant Discodermolide, Macrolactin-A and the antitumour compound Taxol have been made. Dziedzina nauki natural scienceschemical sciencesorganic chemistryaldehydesnatural scienceschemical sciencesorganic chemistryorganic reactionsnatural scienceschemical sciencesorganic chemistryketonesnatural scienceschemical sciencescatalysisnatural scienceschemical sciencesinorganic chemistrymetalloids Program(-y) FP3-HCM - Specific research and technological development programme (EEC) in the field of human capital and mobility, 1990-1994 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator THE UNIVERSITY OF MILANO Wkład UE Brak danych Adres Via Venezian 21 20133 MILANO Włochy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Fundación Bosch i Gimpera de la Universidad de Barcelona Hiszpania Wkład UE Brak danych Adres 21,Balmes 08007 Barcelona Zobacz na mapie Koszt całkowity Brak danych GENT UNIVERSITY Belgia Wkład UE Brak danych Adres Krijgslaan 281 S4 9000 GENT Zobacz na mapie Koszt całkowity Brak danych Philipps-Universität Marburg Niemcy Wkład UE Brak danych Adres Hans Meerwein Straße 35043 Marburg Zobacz na mapie Koszt całkowity Brak danych THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Irlandia Wkład UE Brak danych Adres Belfield 4 Dublin Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF NEWCASTLE UPON TYNE Zjednoczone Królestwo Wkład UE Brak danych Adres Kensington Terrace 6 Bedson Building NE1 7RU NEWCASTLE UPON TYNE Zobacz na mapie Koszt całkowity Brak danych University of Cambridge Zjednoczone Królestwo Wkład UE Brak danych Adres Lensfield Road CB2 1EW Cambridge Zobacz na mapie Koszt całkowity Brak danych Université de Paris XI (Université Paris-Sud) Francja Wkład UE Brak danych Adres 5 rue Jean Baptiste Clément 92296 Châtenay-Malabry Zobacz na mapie Koszt całkowity Brak danych