Obiettivo One of the objectives of the original project is to develop new QSAR models for bioaccumulation, aquatic toxicity and abiotic and biotic degradation. The additional research will focus on: 1. The development of model-based QSAR equations using physiologically compartment models of biosystems. Model-based QSAR equations will be developed for structure-specific binding to cell constituents and for structure-nonspecific distribution processes. These insights will then be applied in the development of QSAR models for the ecotoxicity of non-reactive as well as reactive chemicals. (participant no. 7, in cooperation with participants 1 and 4). 2. The development of new models for biodegradation. The research will focuss on studying the separate processes in biodegradation (sorption, uptake, interaction With the enzyme) and to identify the rate limiting step in the overall process of biodegradation. Insight into these phenomena will lead to predictive models which are understood from a mechanistic point of view. (participant no. 8, in cooperation with participants 1, 4 and 5). The objectives of this project fit very well into the general objectives of the original proposal. The planned research is an additional contribution and extends the scope of the original project. This research will supply more theoretical insights into the QSAR models which will be developed in the original proposal. A better understanding of the models will at the same time increase their potential use for predictions of those environmental parameters which are used in risk assessment. Programma(i) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Argomento(i) 01 - CEEC participation in ENVIRONMENT programme Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UTRECHT UNIVERSITY Contributo UE Nessun dato Indirizzo 50,Yalelaan 2 3584 CL UTRECHT Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Slovak Technical University Slovacchia Contributo UE Nessun dato Indirizzo 9,Radlinského 812 37 Bratislava Mostra sulla mappa Costo totale Nessun dato University Masaryk Cechia Contributo UE Nessun dato Indirizzo 2,Kotlarska 611 67 Brno Mostra sulla mappa Costo totale Nessun dato
