Objective The major aim of the proposed studies is to assess interventions to reduce complications in mother and child due to sexually transmitted diseases. Selected specific objectives include 1) the development of a simplified approach to the diagnosis of gonorrhoea (Go) in pregnancy; 2) to assess the cost-effectiveness of an intervention during pregnancy to prevent perinatal complications related to GO; 3) to examine the feasibility and cost-effectiveness of syphilis prevention during pregnancy; 4) to assess the aetiology and risk factors for post-partum infections (PPI);5) to develop diagnostic criteria for PPI for developing countries. Over 3000 pregnant Women seen at health centres in Nairobi Will be enrolled in a first controlled trial, to asses the risk factors for preterm delivery and PPI;to determine the accuracy of various approaches for the diagnosis of GO during pregnancy; and to define whether an intervention consisting of active detect. and treatment of go during pregnancy results in a reduced incident ceof perinatal complications, particularly prematurity and PPI. In a second prospective study, the impact on pregnancy outcome and child morbidity of a active case detection and treatment programme for syphilis during pregnancy will be compared with current preventive procedures in Nairobi. A total of 1.500 pregnant women will be enrolled in a demonstration intervention healt centre and in a control site With no additional intervention. Women and neonates will be assessed at delivery, and followed for one year. The main outcome measures include the rate of stillbirth, prematurity,and congenital l syphilis. In addition risk factors for syphilis in pregnant Women will be determined, and for pregnancy wastage. A third project consists of a case control study involving 600 women with and without clinical signs and symptoms suggestive of PPI. In this study the incidence, microbial aetiology, and the clinical and histologic features of PPI will be defined and diagnostic criteria for PPI will be developed. Furthermore, the impact of HIV infection on the clinical course of PPI and on the response to treatment will be evaluated. Finally, as part of a risk factor assessment of PPI, antibodies to gonococcal outer membrane peptides will be determined in women with and without PPI. The findings of these studies should allow the development and implementation of simplified interventions for the control of Stds and its complications in pregnancy in the developing world. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineobstetricspostnatal caremedical and health sciencesclinical medicinevenereal diseases Programme(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD EU contribution No data Address 155,Nationalestraat 155 2000 ANVERS /ANTWERPEN Belgium See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address John Radcliffe Hospital - Oxfordshire 5802 OX3 9DU OXFORD/HEADINGTON See on map Total cost No data UNIVERSITY OF NAIROBI Kenya EU contribution No data Address Kenyatta National Hospital 2 NAIROBI See on map Total cost No data
