Cel THE AETIOLOGICAL AGENT OF AIDS, HUMAN IMMUNODEFIECEINCY VIRUS (HIV) IS TRANSMITTED FROM MOTHER TO A CHILD. TRANSMISSION RATES OF HIV VARY WIDELY AND SEVERAL MATERNAL FACTORS CAN INCREASE RISK OF INFECTION. THE NUMBER OF WOMEN INFECTED WITH HIVE IS INCREASING AND MAJORITY OF THESE ARE OF CHILD BEARING AGE. THERAPEUTIC AND PROPHYLACTIC INTERVENTIONS DESIGNED TO INTERRUPT TRANSMISSION OF HIV FROM AN INFECTED WOMAN TO HER NEW BORN ARE ESSENTIAL. AN UNDERSTANTDING OF THE PATHOGENESIS OF HIV INFECTION IN PREGNANT WOMAN AND INFANTS IS CRUCIAL FOR DEVELOPMENT OF THESE. CONFLICTIN INFORMATION IS AVAILABLE WITH REGARD TO THE EFFECT OF HIV ON PREGNANCY OUTCOME. TRANSPLACENTAL PASSAGE OF HIV HAS BEEN DOCUMENTED TO OCCUR AS EARLY AS 8 WEEKS OF PREGANCY. LITTLE WORK HAS BEEN DONE WITH RESPECT TO THE PATHOGENESIS AND RISK FACTORS ASSOCIATED WITH EARLY TRANSMISSION ROLE OF PLACENTA IN PERINATAL TRANSMISSION, OR PLACENTAL DYSFUNCTION ASSOCIATED WITH HIV INFECION. HUMAN TROPHOBLAST CAN BE INFECTED WITH HIV IN VITRO AND THESE CELLS CAN SUSTAIN THE WHOLE VIRUS CYCLE. IT HAS ALSO BEEN SHOWN THAT HUMAN TROPHOBLAST PRODUCES INTERFERONS WHICH MAY INFLUENCE OUTCOME OF HIV INFECTION. 1. CHARACTERIZATION OF PLACENTAL CELL TYPES WITH RESPECT OF CD4 AND HIV/SIV INFECTION. 2. STUDY THE ROLE OF TROPHOBLAST INTERFERONS IN PLACENTA WITH RESPECT TO HIV INFECTION. 3. IDENTIFICATION OF MORPHOLOGICA CHARACTERISTICS OF PLACENTA SPECIFIC FOR HIV INFECTION. THE CORRELATION BETWEEN CHORIOAMNIONITIS AND LEAKINESS OF TROPHOBLAST BARRIER IN RELATION TO VERTICAL TRANSMISSION WILL BE STUDIED. 4. TIMING OF PERINATAL INFECTION AND VERTICAL TRANSMISSION OF SIV WILL BE STUDIED IN BABOONS. LIMITED STUDIES ON THIS ASPECT WILL BE DONE IN CHIMPANZEES. Dziedzina nauki natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineobstetrics Program(-y) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator DANISH CANCER SOCIETY Wkład UE Brak danych Adres 10,Gustav Wieds Vej 10 8000 AARHUS C Dania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD Belgia Wkład UE Brak danych Adres 155,Nationalestraat 155 2000 ANVERS /ANTWERPEN Zobacz na mapie Koszt całkowity Brak danych NATIONAL MUSEUMS OF KENYA Kenia Wkład UE Brak danych Adres 00403 KAREN Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF NAIROBI Kenia Wkład UE Brak danych Adres Kenyatta National Hospital 2 NAIROBI Zobacz na mapie Koszt całkowity Brak danych