Objective
Genetic variability of malaria parasites represents a major obstacle to control strategies based either on therapy or on prevention. Emergence of drug-resistant forms already limits the usefulness of existing drugs, and selection of antigenic variants may rapidly nullify the action of newly developed vaccines. Variability is not only recorded among different geographical isolates, but also over time in the course of individual infections. The ability to change its own genetic make-up in response to different kinds of pressures most likely confers a selective advantage to the parasite. Genome studies are of fundamental importance in order to understand the nature of variation, which might take place both by gene mutation and recombination mechanisms and through genomic rearrangements. Accordingly, the project intends to study genome structure and dynamics at different levels, and to integrate information obtained with different methodologies. Population genetics studies on natural P.falciparum populations will provide important data, and possibly models, for the spread of defined genetic characters (eg. drug resistance). Defining patterns of allelic segregation in the progeny of a single meiotic event will help clarify the mechanism of meiotic recombination in the organism and its importance in natural interbreeding populations. The remarkable genomic polymorphism observed in molecular karyotypes in the course of mitotic multiplication will be studied by mapping the size variations to specific chromosomal regions. This might facilitate localisation of particular functions by deletion mapping. Finally, the dynamics of mobile elements and their possible role in the process of genomic diversification will be studied. The following lines will be activated:
1- Genetic polymorphism in natural P. falciparum populations. 1.1.a) Frequency of cross-fertilization in natural populations. 1.1.b) Frequency of recombination in single hybrid oocysts.
1.2 Spatial scale of P. falciparum populations.
1.3 Diversity of S-anti gen alleles Within an endemic area.
2- Karyotype polymorphism. 2.1. Technical improvements.
2.2 Deletion mapping of dispensable functions.
2.3 Subtelomeric structures and genes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics genomes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH9 3JT EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.