Objetivo THIS PROJECT WILL INVESTIGATE THE DEVELOPMENT OF IMMUNITY TO THE ERYTHROCYTIC STAGES OF THE MALARIA PARASITE, PLASMODIUM FALCIPARUM, WITHIN A DEFINED ENDEMIC AREA IN BENIN, WEST AFRICA. THE SPECIFICITY AND FUNCTION OF RESPONDING T CELLS WILL BE STUDIED WITH REFERENCE TO RESPONSES WHICH CORRELATE WITH THE DEVELOPMENT EITHER OF THE PATHOLOGY OF THIS DISEASE OR WITH PROTECTIVE IMMUNITY. THE PHERNOTYPE AND FUNCTION OF T CELLS RESPONDING TO ENTIGENS OF P. FALCIPARUM WILL BE COMPARED AMONGST INDIVIDUALS OF DIFFERING AGE, DISEASE AND IMMUNE STATUS. THESE INDIVIDUALS WILL ALSO BE STUDIED FOR THEIR RESPONSES TO SELECTED DEFINED ANTIGENS (MSA-1, MSA-2, AMA-1 AND S-ANTIGENS) AND TO OTHER PROTEINS OF THE PARASITES. THE EFFECTS OF IMMUNE PRESSURE ON VARIABILITY ON THESE ANTIGENS WILL BE INVESTIGATED TOGETHER WITH A STUDY OF THE PEPTIDES WHICH ARE PREESENTED TO T CELLS. THIS WILL DETERMINE WHETHER THE PEPTIDES RECOGNISED BY IMMUNE CELLS ARE THOSE AFFECTED BY IMMUNE PRESSURE AND WHETHER THESE ANTIGENS ARE SUITABLE CANDIDATES FOR INCORPORATION IN A MALARIA VACCINE. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinepathology Programa(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Max-Planck-Gesellschaft zur Forderungder Wissenschaften e.V. Aportación de la UE Sin datos Dirección Stübeweg 51 79108 Freiburg Alemania Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Centre National Hospitalier et Universitaire Cotonou Benín Aportación de la UE Sin datos Dirección Cotonou Ver en el mapa Coste total Sin datos MRC National Institute for Medical Research Reino Unido Aportación de la UE Sin datos Dirección The Ridgeway Mill Hil NW7 1AA London Ver en el mapa Coste total Sin datos Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek Países Bajos Aportación de la UE Sin datos Dirección 157,Lange Kleiweg 2280 GH Rijswijk Ver en el mapa Coste total Sin datos United Medical and Dental Schools of Guy's and St Thomas's Hospitals Reino Unido Aportación de la UE Sin datos Dirección London Bridge SE1 7EH London Ver en el mapa Coste total Sin datos Université Nationale de Bénin Benín Aportación de la UE Sin datos Dirección Cotonou Ver en el mapa Coste total Sin datos
