Cel TRANSMISSION OF MALARIA PARASITES FROM MAN TO MOSQUITO REQUIRES THE PRESENCE OF SEXUAL STAGES IN THE BLOOD BUT THE PROCESS IS DETERMINED BY COMPLICATED AND ENIGMATIC FACTORS. AIM OF THE SEXUAL STAGE VACCINE IS BLOCAGE OF TRANSMISSION, AND KNOWLEDGE ABOUT THE VARIOUS FACTORS HELPS ITS DEVELOPMENT. INFECTIVITY OF GAMETOCYTES IN THE FIELD CANNOT DIRECTLY BE ESTIMATED USING THE PARASITIC DEVELOPMENT BOTH BY FACTORS FROM THE HUMAN HOST AND THE MOSQUITO VECTOR. THE PROJECT APPROACHES TRANSMISSION MECHANISTICS OF PLASMODUM FALCIPARUM IN CAMEROON FROM THE EXPERIMENTAL SIDE AS WELL AS EPIDIOMINOLOGICALLY. THE PRESENCE OF TRANSMISS. REDUCING FACTORS IS DETECTED BY PERFORMING EXPERIMENTAL FEEDINGS OF BLOOD FROM GAMETOCYTE CARRIERS TO LOCALLY REARED ANOPHELINES. THE NATURE OF THESE FACTORS, BE THEY PHASE PROTEINS AND THEIR EFFECTS ALONG THE SPOROGONIC DEVELPMENT WILL BE ANALISED. THE PRESENCE OF TRANSMISSION BLOCKAGE IS ALSO DETECTED IN HUMAN POPULATIONS UNDER VARIOUS DEGREES OF EXPOSURE TO INFECTED MOSQUITOS THROUGHOUT THE YEARLY CYCLE OF SEASONS, IN AGE GROUPS AND IN HEALTHY AND SICK PEOPLE. NEWLY DEVELOPED ELISAS FOR ANTIBODIES AGAINST 45/48 AND 230 KD GAMETE PROTEINS WILL BE INTRODUCED AND APPLIED LOCALLY, WHILST A BIO ASSAY WITH CULTURED GAMETOCYTES AND MOSQUITOES IS AT HAND TO EXTEND THE DATA FROM THE FIELD. THE PROJECT IS A CONCERTED ACTION OF THE UNIVERSITY NIJMEGEN ORSTOM PARIS AND OCEAC YAOUNDE THE REQUESTED DUTCH HALFTIME POSTDOC AND THE AFRICAN PHYSICIAN WILL CARRY OUT MOST OF THEIR RESEARCH IN CAMEROON FOR A PERIOD OF THREE YEARS. Dziedzina nauki medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinessocial sciencespsychologyergonomicsnatural sciencesbiological scienceszoologyinvertebrate zoology Program(-y) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator STICHTING KATHOLIEKE UNIVERSITEIT Wkład UE Brak danych Adres 6500 GL NIJMEGEN Niderlandy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Institut Français de Recherche Scientifique pour le Développement en Coopération - ORSTOM Francja Wkład UE Brak danych Adres Rue La Fayette 213 75010 Paris Zobacz na mapie Koszt całkowity Brak danych Organisation de Lutte Contre les Endémies en Afrique Centrale Kamerun Wkład UE Brak danych Adres Yaounde Zobacz na mapie Koszt całkowity Brak danych
