Obiettivo GENERAL AND LONGTERM OBJECTIVES: 1-IDENTIFY THE TARGET ANTIGENS OF ACQUIRED IMMUNITY("PREMUNITION") FOR VACCINATION PURPOSES. 2-PRODUCE THERAPEUTIC ANTIBODIES BY DNA RECOMBINANT TECHNIQUES. SPECIFIC OBJECTIVES. 1-ISOLATE ANTIBODIES WITH WRLL-DEFINED SPECIFICITIES BY AFFINITY-PURIFICATION OF HUMAN IMMUNE IgG ON RELEVANT PEPTIDES AND ASSESS THEIR IN VIVO EFFICIENCY BY PASSIVE TRANSFER IN RECRUDESCENT ASYMTOMATICP.FALCIPARUM CASES. 2-DEVELOP THE TECHNOLOGY OF RECOMBINANT HUMAN ANTIBODIES SPECIFIC OF PF. ANTIGENS AS A MEANS TO PRODUCE LARGE AMOUNTS OF THE SAME ANTIBODY SPECIFICITIES WHICH MAY PROVE TO BE EFFECTIVE BY PASSIVE TRANSFER(OBJ.1) AND WHICH COULD BE USED FOR CLINICAL TREATMENT. 3-FURTHER EPIDEMIOLOGICAL STUDIES BY MEANS OF IN-VITRO CELL-ANTIBIDY COOPERATION ASSAYS(ADCI)IN ORDER:i)TO CONFIRM THE RELEVANCE OF THE TARGET ANTIGENS ALREADY SELECTED,IDENTIFY CROSS-REACTIVE EPITOPES,IF ANY,AND ii)TO DEFINE IF THERE ARE OTHER ANTIGENS TARGETTED BY DEFENSE MECHANISMS. Campo scientifico medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore INSTITUT PASTEUR Contributo UE Nessun dato Indirizzo Rue du Docteur Roux 28 75724 PARIS Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Institut Pasteur de Lille Francia Contributo UE Nessun dato Indirizzo 1 rue du Professeur Albert Calmette 59019 Lille Mostra sulla mappa Costo totale Nessun dato Mahidol University Thailandia Contributo UE Nessun dato Indirizzo 420,Rajviti Road 10400 Bangkok Mostra sulla mappa Costo totale Nessun dato Rigshospitalet København Danimarca Contributo UE Nessun dato Indirizzo 9,Blegdamsvej 2100 København Mostra sulla mappa Costo totale Nessun dato
