Objective The overall project is based on the study of mouse models generated with the gene targeting and the transgenic technology in order to investigate the mechanism of immune responsiveness and unresponsiveness relevant to autoimmunity.Studies on the following mouse models have been carried out:1) Lysozyme transgenic mice.2) TcR (anti-IgG2a{b}) transgenic mice.3) beta2-microglobulin gene deficient mice.4) A CD3-epsilon gene deficient mice.5) Cell type specific Cre recombinase gene transgenic mice; cytokine receptor gene mutants carrying 'floxed gene' for conditional knock out mice.1) Tg mouse model of controlled autoimmune disease2) Tg mouse model of class II restricted self antigen (Ig) presentation3) A mouse model of Th1/Th2 polarization4) A CD3 mutated mouse model for thymic selection5) New cre-recombinase Tg mouse lines useful for the application of somatic gene alteration. Fields of science medical and health sciencesbasic medicineimmunologyautoimmune diseases Programme(s) FP3-BIOTECH 1 - Specific research and technological development programme (EEC) in the field of biotechnology, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT PASTEUR EU contribution No data Address 25,Rue du Docteur Roux 28 75724 PARIS France See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Parc Scientifique et Technologique de Luminy 13288 MARSEILLE See on map Total cost No data Roche SpA Italy EU contribution No data Address Piazza Durante 11 20131 Milano See on map Total cost No data Università degli Studi di Milano Italy EU contribution No data Address Via Vanvitelli 32 20129 Milano See on map Total cost No data Universität Köln Germany EU contribution No data Address Weyertal 121 50931 Köln See on map Total cost No data
