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Contenuto archiviato il 2024-04-16

Vanadium derivates as transition state analogs in ribonucleases and as haptens for the production of antibodyenzymes (abysymes) with phosphatase activity

Obiettivo



The two fundamental goals of this project are:
- The further study of vanadate compounds mainly nucleotides as stable transition-state analogs for pentavalent phosphate
intermediates in reactions catalyzed by ribonuclease-T1. This involves mainly 51V-NMR and X-ray crystallography.
- The exploitation of this property of vanadate compounds to mimic transition state intermediates of phosphohydrolysis reactions, to use them, now as haptens for the production of antibodies with phosphohydrolytic capacity.

Argomento(i)

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Invito a presentare proposte

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Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

Vrije Universiteit Brussel
Contributo UE
Nessun dato
Indirizzo
65,Paardenstraat 65
1640 Rhode-Saint-Genèse
Belgio

Mostra sulla mappa

Costo totale
Nessun dato

Partecipanti (2)