Obiettivo Chronic arthritis is of major public health importance to the European Community and this Concerted Action brings together laboratories to form a cohesive unit that will uniquely be able to carry out the research proposals described to tackle arthritis. The European laboratory that has been formed by this Concerted Action focuses upon the four areas of glycobiology. Glycoproteins (Immunoglobulin G and acute phase proteins) Oligosaccharide molecular modelling. Cell adhesion molecules. The glycosyltransferase This proposal seeks to expand and consequently make more scientifically effective our recently established Concerted Action involving oligosaccharides and arthritis. The areas selected for expansion fall into two crucial areas: Oligosaccharides and Proteins. (a) The role the oligo-saccharide moiety of human IgG-Fc plays in determining i ternary structure will be elucidated together with insight into its interaction sites for ligands. (b) The glycosylation dependent biological functions of rheumatoid factors will be determined. (c) Characterisation of IgG glycosylation in psoriatic arthritis will be determined. The Glycosyltransferases. (a) A system for modulation of protein oligosaccharide characteristics by glycosyltransferase gene transfer will be developed, together with clinical protocols for gene therapy. (b) Modulation of the expression of the a-1,3/4-fucosyltransferase (FT III) responsible for the synthesis of Lex and Lea structures will be investigated. These areas have been selected for expansion as they integrate well into the main focus of the Concerted Action, which is to elucidate the mechanisms wh inflammatory process and, how these mechanisms may be inhibited to bring about amelioration of the inflammation process resulting in arthritis. Programma(i) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Argomento(i) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore St George's Hospital Medical School Contributo UE Nessun dato Indirizzo Cranmer Terrace SW17 0RE London Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Institute of Immunology - Russian Academy of Medical Sciences Russia Contributo UE Nessun dato Indirizzo 14,Yadrintsovskaya Street 630091 Novosibirsk Mostra sulla mappa Costo totale Nessun dato University School of Medical Sciences Polonia Contributo UE Nessun dato Indirizzo 15,Garbary Street 61 866 Poznan Mostra sulla mappa Costo totale Nessun dato
