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Contenido archivado el 2022-12-23

Laser-Doppler Flowmetry for Microcirculation Monitoring

Objetivo



The skin showing an active psoriatic skin lesion exhibits an about 4 times increase in the blood flow by laser dopper flowmetry.
Following a succesful therapy, the mean blood flux usually returns to the normal.
This method was also found to be useful for the distinction between the active and inactive edge of the psoriatic lesions. Our aim is to provide basic data in the framework of the concerted action for the efficacy of therapy in patients with psoriasis. For this purpose, the affected skin of 30 patients with newly recognized psoriasis will be investigated before starting the treatment. After therapy (including PUVA, retinoid, cortico-steroid treatment) identical skin regions (mainly elbows, knees and scalp) will be reinvestigated.

On a later phase of the study, we try to examine the effectivenes of different therapies on the evolution of the psoriatic lesion. The data in the literature collected on small number of patients indicate that the laser doppler assesment of the stage of the lesion may be of benefit. The localised scleroderma is also if interest because an increase in mean blood flux was described in either the perilesional or the sclerotic areas. The latter is unusual, because capillary injury is usually present in the affected skin.

We plan to reinvestigate this question in 20 patients with localized scleroderma (morphea) intending to clarify the causes of the unusual increased blood flow in the sclerotic and perilesional area. Different forms of circumscribed scleroderma including linear scleroderma and generalized morphea will be studied and compared. Our aim is to provide basic information in the framework of the concerted action for the mean blood flux in localized scleroderma, and in the later stage of the project to get some information about the efficacy of the therapy in this disorder.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

Medizinische Universität Lübeck
Aportación de la UE
Sin datos
Dirección
Ratzeburger Allee 160
23562 Lübeck
Alemania

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Coste total
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Participantes (3)