Objective
The purpose of the research is to assess the value of new methods, such as the N2 test, measurement of the impedance of the ventilatory system and analysis of the expired CO2 curve, for diagnosing and monitoring occupational respiratory diseases, in particular coalminer's pneumoconiosis.
This evaluation of the diagnostic and prognostic value of the tests (both individually and in combination) may result in more effective prevention of the disease.
The research will be in two parts:
1) The first part will be a prospective epidemiological study of "exposed subjects" and "controls". The exposed subjects will be 100 coalminers who have worked for at least 10 years in dusty situations; the controls will also be underground workers but they will not have been exposed for more than 2 years. The subjects will be given and ECSC questionnaire and will undergo clinical examinations, radiological examinations and respiratory function examinations (traditional and "sensitive") each year.
2) Development of computerized apparatus for instantaneous analysis of distortions in the expired CO2 curve as a function of time and volumes.
METHODS AND MEANS BY WHICH THE AIMS ARE TO BE ACHIEVED
The subjects will undergo respiratory function examinations featuring "traditional" tests (measurements of volumes and maximum and mean flows, Steady-state and single-breath CO transfer test, measurements of thoracic gas volumes by plethysmography) and "sensitive" tests (N2 test after a single inhalation of O2, measurement of the impedance of the mechanical ventilatory system by forced oscillation techniques, analysis of the expired CO2 curve).
Research concerning the CO2 curve will involve verification of its physiopathological basis and evaluation of the reproducibility of its measurement in thealthy subjects and diseased subjects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
54505 VANDOEUVRE LES NANCY
France
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