Objective Complementary strategies to identify diabetes genes will be applied, such as 1) random mapping of the total human genome from several hundred well-characterized NIDDM families, with highly informative DNA markers for a systematic search for chromosomal regions co-segregating in subtypes of NIDDM, 2) positional cloning in cases where chromosomal localization does not reveal known candidate genes, 3) cloning of a series of candidate genes and screening of these genes for disease-causing mutations, 4) identification of new NIDDM candidate genes by mRNA-differential display in muscle biopsies from insulin resistant NIDDM-patients, 5) genetic studies of animal modes, eg. the GK-rat, and extrapolation of the results to human NIDDM and 6) studies of early onset NIDDM families (MODY) which are negative for linkage to glucokinase or adenosine deaminase genes. Defining the nature of the NIDDM genes will allow early identification of high risk individuals who may benefit from early medical intervention and thereby the prevention of NIDDM in many cases. Knowledge of the genetics of NIDDM will also give the basis for the development of specifically targeted antidiabetic drugs and/or gene therapy in some cases. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Topic(s) 5.3 - Role of gene and gene products in disease aetiology and pathogenesis Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE EU contribution No data Address 1,Rue du Professeur Calmette 1 59019 LILLE France See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all Institut National de la Santé et de la Recherche Médicale France EU contribution No data Address 1,Avenue Claude Vellefaux 75475 Paris See on map Total cost No data Lund University Sweden EU contribution No data Address 214 01 Malmö See on map Total cost No data NOVO-NORDISK A/S Denmark EU contribution No data Address Niels Steensens Vej 2 2820 GENTOFFE See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address Roosevelt Drive OX3 7BN OXFORD/HEADINGTON See on map Total cost No data Université de Paris VII France EU contribution No data Address 2,Place Jussieu 75251 Paris See on map Total cost No data
