Objective Oxidant damage has been implicated in the pathology of a number of human diseases including cardiovascular disease and cancer and important biological defence systems have evolved to limit such damage. These antioxidant defences are inter alia dependent on dietary antioxidants. There is now substantial evidence that an optimum level of Cu is required to maintain antioxidant defence systems within the body and that Cu deficiency in animals increase oxidant stress. Although severe or clinically-defined Cu deficiency in humans is not a public health problem, there is concern by some that a disparity may exist between putative Cu requirements and mean apparent intakes in Western populations resulting in widespread mild, sub-clinical Cu deficiencies. Dietary Cu requirements are uncertain but must published recommended dietary intakes vary around 1-2mg/d. The majority of dietary intakes in Western populations are around or below these values.The information provided by the research should give a better understanding of the precise requirements for dietary Cu and elucidate the balanced interactions which occur within the whole diet with respect to Cu.The technical and scientific objectives of this research are :- to provide data on the significance of increased dietary Cu (provided by Cu supplements) as a pro-oxidant or antioxidant in vivo in both free-living men and women;- to provide data on how formulated low, medium and high Cu diets fed to male and female volunteers in metabolic units can affect risk factors for cardiovascular disease, fructose/copper interactions and biomarkers of bone turnover;- to provide data on Cu bioavailability in humans using an oral challenge of 65Cu stable isotope;- to provide in vitro data on the molecular mechanisms of Cu absorption and metabolism in the intestinal cell and on the effects of the interactions of Cu with other components of the diet. Fields of science medical and health scienceshealth sciencespublic healthmedical and health scienceshealth sciencesnutritionmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathology Programme(s) FP4-FAIR - Specific research, technological development and demonstration programme in the field of agriculture and fisheries (including agro-industry, food technologies, forestry, aquaculture and rural development), 1994-1998 Topic(s) 3.1.2 - Role of diet in diseases and disorders Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator University of Ulster EU contribution No data Address Cromore Road BT52 1SA Coleraine United Kingdom See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all BBSRC Institute of Food Research United Kingdom EU contribution No data Address Norwich Research Park Colney Lane NR4 7UA Norwich See on map Total cost No data I.N.R.A. - CENTRE DE RECHERCHE DE CLERMONT - THEIX France EU contribution No data Address 63122 SAINT-GENES-CHAMPANELLE See on map Total cost No data Istituto Nazionale della Nutrizione Italy EU contribution No data Address Via Ardeatina 546 00179 Roma See on map Total cost No data ROYAL VETERINARY AND AGRICULTURAL UNIVERSITY Denmark EU contribution No data Address ROLIGHEDSVEJ, 30 1958 FREDERIKSBERG C See on map Total cost No data Rowett Research Institute United Kingdom EU contribution No data Address Greenburn Road Bucksburn AB2 9SB Aberdeen See on map Total cost No data THOMSON & JOSEPH LTD. United Kingdom EU contribution No data Address NORTH MAIN STREET, 101 84105 CLEARFIELD See on map Total cost No data UNIVERSITY COLLEGE CORK Ireland EU contribution No data Address WESTERN ROAD CORK See on map Total cost No data