Obiettivo . To begin systematic monitoring of semen quality and prevalence of cryptorchidism and hypospadias among newborns in several regions of Europe. To develop rapid in vivo and in vitro screening systems for the detection of oestrogenic and anti-androgenic potency of the most abundant environmental chemicals . To identify the threshold levels of exposure to environmental chemicals which have been identified as xenoestrogens and their effects on the reproductive system (including expression of several developmental genes) in animal models. To evaluate exposure of greenhouse workers to selected xenoestrogens which are constituents of commonly used pesticides. To identify the targets for xenoestrogens at the molecular level. To investigate a possible link between environmental hormone disruptors and neoplastic transformation of testicular germ cellsSeveral aspects of male reproductive health have changed dramatically for the worse over the past 50 years. A striking decline in sperm counts in the semen of normal men has been reported in several countries. At the same time the incidence of testicular cancer has increased progressively to become now the most common cancer in young men. Prevalence of other disorders of the male reproductive tract such as hypospadias and cryptorchidism appears to be increasing as well, however with marked geographic differences in Europe. These adverse changes in reproductive health are probably inter-related and may have a common origin in foetal life. It has been well established that exposure of the male foetus to supranormal levels of oestrogens or anti-androgens can result in similar reproductive defects. The growing number of reports demonstrating that common environmental contaminants e.g. PCBs, alkylphenols, phtalates and DDT metabolites possess oestrogenic or anti-androgenic activity presents the working hypothesis that the adverse trends in human male reproductive health may be, at least in part, associated with exposure to environmental chemicals during foetal and childhood development. To explore the problem and test this hypothesis, a substantial research effort using interdisciplinary and multinational approach is needed. Several European laboratories which have been engaged in active basic and clinical research in various areas of expertise (male reproduction, epidemiology, occupational medicine, endocrinology, germ cell differentiation, molecular and cellular biology), formed a consortium in order to continue investigations in more co-ordinated and effective manner. The ultimate goal is to identify the possible environmental sources of hormonal disruptors, to increase knowledge on the mechanisms of their action, and to develop a strategy for prevention. Campo scientifico medical and health sciencesclinical medicineandrologymedical and health scienceshealth sciencessocial biomedical sciencessexual healthmedical and health sciencesclinical medicineobstetricsfetal medicinemedical and health sciencesclinical medicineoncologynatural sciencesearth and related environmental sciencesenvironmental sciencespollution Programma(i) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Argomento(i) 4.5.8 - Risk factors of occupational and environmental diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore COPENHAGEN UNIVERSITY HOSPITAL Contributo UE Nessun dato Indirizzo 9,Blegdamsvej 9 2100 KOEPENHAGEN Danimarca Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Brunel University Regno Unito Contributo UE Nessun dato Indirizzo Kingston Lane UB8 3PH Uxbridge Mostra sulla mappa Costo totale Nessun dato Institut National de la Santé et de la Recherche Médicale Francia Contributo UE Nessun dato Indirizzo Avenue du Général Leclerc 35042 Rennes Mostra sulla mappa Costo totale Nessun dato Medical Research Council Regno Unito Contributo UE Nessun dato Indirizzo 37 Chalmers Street EH3 9EW Edinburgh Mostra sulla mappa Costo totale Nessun dato Odense Universitet Danimarca Contributo UE Nessun dato Indirizzo 17,Winsloewparken 5000 Odense Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF TURKU Finlandia Contributo UE Nessun dato Indirizzo 10,Kiinamyllynkatu 10 20520 TURKU / ABO Mostra sulla mappa Costo totale Nessun dato Université de Paris V 'René Descartes' Francia Contributo UE Nessun dato Indirizzo 123,BOULEVARD DE PORT-ROYAL 75014 PARIS Mostra sulla mappa Costo totale Nessun dato