Obiettivo To demonstrate the safety and practicability of boron neutron capture therapy (BNCT) as radiotherapy modality.To demonstrate which are the optimal treatment conditions for glioma treatment with boron neutron capture therapy and Na2B12H11SH (BSH) as boron carrier.To demonstrate the use of a centralized European treatment center in multi-country treatment.The proposed Demonstration Project is for a Phase I/II study of glioma treatment with boron neutron capture therapy (BNCT). It has as objective to investigate whether BNCT with epithermal neutrons and Na2B12HllSH (BSH) as boron compound is a safe, and an effective, treatment of glioma. This will be achieved through the treatment of patients, with patient survival and quality of survival as measurable parameters. The study will show what the maximum irradiation level is for safe BNCT with BSH, and whether irradiation at or before maximum tolerated dose will result in partial or complete tumour control. It will be investigated to which extent treatment conditions can influence the outcome for the patients. Emphasis will be put on safety for the patient and effectiveness of treatment. The program will eventually demonstrate whether the therapeutic ratio of BNCT can surpass that of other radiotherapy modalities for glioma. Thus, it falls within area 4.1 Cancer Research subsection 4.1.8 Assessment of treatment modalities. If successful, it will lead to the introduction of a new cancer therapy modality into the clinical reality. The clinical research proposed will therefore facilitate the transition of BNCT into clinical use. It can only be carried out in the framework of a Demonstration Project. Europe has, among the participating partners, all necessary knowledge and experience to carry out the project in a competent and effective manner. Campo scientifico medical and health sciencesclinical medicineoncologynatural scienceschemical sciencesinorganic chemistrymetalloids Programma(i) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Argomento(i) 8.2 - Demonstration Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITAET BREMEN Contributo UE Nessun dato Indirizzo Leobener Strasse 28334 Bremen Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Svizzera Contributo UE Nessun dato Indirizzo Rue du Bugnon 46 1011 LAUSANNE Mostra sulla mappa Costo totale Nessun dato Centre Antoine Lacassagne Francia Contributo UE Nessun dato Indirizzo 227,Avenue de la Lanterne 06200 Nice Mostra sulla mappa Costo totale Nessun dato Commission of the European Communities Paesi Bassi Contributo UE Nessun dato Indirizzo 3,Westerduinweg 1755 ZG Petten Mostra sulla mappa Costo totale Nessun dato Karl-Franzens-Universität Graz Austria Contributo UE Nessun dato Indirizzo Auenbruggerplatz 8036 Graz Mostra sulla mappa Costo totale Nessun dato Ludwig-Maximilians-Universität München Germania Contributo UE Nessun dato Indirizzo 15,Marchioninistraße 81366 München Mostra sulla mappa Costo totale Nessun dato Netherlands Energy Research Foundation Paesi Bassi Contributo UE Nessun dato Indirizzo 3,Westerduinweg 1755 LE Petten Mostra sulla mappa Costo totale Nessun dato Universität Gesamthochschule Essen Germania Contributo UE Nessun dato Indirizzo 55,Hufelandstrasse 45122 Essen Mostra sulla mappa Costo totale Nessun dato Zentralkrankenhaus St.-Jürgen-Strasse Germania Contributo UE Nessun dato Indirizzo St.-Jürgen-Strasse 28205 Bremen Mostra sulla mappa Costo totale Nessun dato