Obiettivo The objectives of the project are to provide knowledge for the prevention of waste dust related disease through: * Coordination and optimization of ongoing research projects, * Identification of causative agent(s) and pathological reactions caused by these, development of a measurement strategy, * Evaluation of the no reaction threshold, based on dose response relationships, for establishment of guidelines, * Develop improved diagnostic criteria for disease caused by waste handling and, * Develop information material to disseminate knowledge for preventive programmesInitially, a review of information on waste dust exposure and disease will be made. This material, which is going to be continuously updated, will be available for outside use. The scientific data base will be analyzed and a state of the art article for publication in a scientific journal will be prepared. Investigations will be made of exposure conditions in waste processing facilities with different technical characteristics and with particular reference to airborne dust, bacterial endotoxin and (1->3)-B-D-glucan - a cell wall component of moulds. The importance of source characteristics, storage and waste collection for the worker exposure will be studied. Workers engaged in different parts of the waste handling industry will be examined with particular reference to the presence of airways inflammation and asthma. Persons will be challenged with bacterial endotoxin and extracts of waste dust to study the development of inflammation and obtain a basis for a no reaction threshold. In these experiments, new effect and endpoints in terms of inflammatory markers and cell reactivity will be evaluated. Animal experiments will be made to study the mechanisms behind the diseases present among waste workers with particular reference of bacterial endotoxin and (1 ->3)-B-D-glucan from mould cell walls. Information material for researchers, workers and management will be prepared. Campo scientifico medical and health sciencesclinical medicinepneumologyasthmaengineering and technologyenvironmental engineeringwaste managementnatural sciencesbiological sciencesmicrobiologybacteriology Programma(i) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Argomento(i) 4.5.8 - Risk factors of occupational and environmental diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore GOETEBORG UNIVERSITY Contributo UE Nessun dato Indirizzo 16,Medicinaregatan 16 405 30 GOETEBORG Svezia Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Institut Pasteur Francia Contributo UE Nessun dato Indirizzo 25,Rue du Docteur Roux 75724 Paris Mostra sulla mappa Costo totale Nessun dato Institut de Recherche Appliquée en Allergologie et Immunologie Clinique Svizzera Contributo UE Nessun dato Indirizzo 15,Rue Lombard 1205 Genève Mostra sulla mappa Costo totale Nessun dato Landbouwuniversiteit Wageningen Paesi Bassi Contributo UE Nessun dato Indirizzo 6700 AE Wageningen Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF AARHUS Danimarca Contributo UE Nessun dato Indirizzo 180,Vennelyst Boulevard, 6 8000 AARHUS C Mostra sulla mappa Costo totale Nessun dato Universidade Nova de Lisboa Contributo UE Nessun dato Indirizzo Mostra sulla mappa Costo totale Nessun dato University of Luton Regno Unito Contributo UE Nessun dato Indirizzo Park Square LU1 3JU Luton Mostra sulla mappa Costo totale Nessun dato Università degli Studi di Ferrara Italia Contributo UE Nessun dato Indirizzo Via Fossato di Mortara 23 44100 Ferrara Mostra sulla mappa Costo totale Nessun dato Université Libre de Bruxelles Belgio Contributo UE Nessun dato Indirizzo 322,Rue Haute 1000 Bruxelles Mostra sulla mappa Costo totale Nessun dato
